Protein-based approaches have relied on genetic, biochemical, and immunological analyses to identify the specificity of protective antibodies to polypeptide antigens. Genomics has also enabled the identification of new vaccine antigens. Once the complete sequence (or portions thereof) of the genomic DNA...
(the globotriose blood group antigen).80Globotriose-GNPs showed size- and linker length-dependent affinity for the protein, and were used as multivalent probes for thepurificationof the B-subunit from cell lysates. The group of Kamerling has also evaluated the interaction between ConA and ...
AntigenDB AntigenDB is a manually curated database of experimentally verified antigens that includes detailed information about the antigen, the source organism, and the associated antibodies CAMEO CAMEO (Continuous Automated Model EvaluatiOn) is a project for the automated evaluation of methods predicting...
CD8 is a glycoprotein present on approximately one-third of T cells in lieu of CD4. Similar to CD4, it binds to a monomorphic region MHC, although it binds to class I rather than to class II antigens. CD8 defines cytotoxic effector cells and perhaps subsets of natural killer and regulatory...
(CH-π stacking interactions), generating a hydrophobic core. PPα-Tyr, a mini-protein designed by Woolfson et al., was designed by combining two protein fragments: surfaceadhesinand antigen (AgI/II) fromStreptococcusmutants and bovine pancreaticpolypeptide hormone. PPα-Tyr proved to fold ...
Autoantibodies from SLE patients cross-react with similar antigens present in rodent, brine shrimp, and yeast cells, demonstrating that the proteins and their epitopes have been conserved. Although the major epitope recognized by SLE sera resides within a 22 amino acid domain in the carboxyl-termina...
Retinol-binding protein (RBP) is a low molecular weight protein (molecular weight of free form: 21,400 kDa), which is bound to transthyretin (MW 55,000 kDa) in plasma. The unbound fraction is filtered freely through the glomeruli, and 99.97% of it is reabsorbed by the proximal renal tub...
N-terminal free tau antibodyGosuranemabPSPYesWorse globallyDam et al. (2021) TilavonemabPSPYesWorse globally, brain atrophyHoglinger et al. (2021) SemorinemabProdromal-mild ADYesNo benefitTeng et al. (2022) Amyloid Aβ Aβ antigenAN-1792Mild–moderate ADYesNo benefit, toxicGilman et al....
Their activation requires not only the direct stimulation of foreign antigens, but also the co-stimulus signal transmitted by the interaction of surface molecules.148 The CD40/CD40L pathway is one of the most important co-stimulating pathways in T-cell activation. Because of its critical role in...
Predicting interactions between proteins and other biomolecules solely based on structure remains a challenge in biology. A high-level representation of protein structure, the molecular surface, displays patterns of chemical and geometric features that fingerprint a protein’s modes of interactions with oth...