Summary: The protein-protein interaction data available today in databases were either determined by experimental methods or predicted by computational methods. Biologists studying a certain mechanism or function are usually interested in a small-scale network of protein-protein interactions related to the...
Protein-protein interaction is important in molecular and cellular biology for catalysis, regulation, immune response, and inhibition. Therefore, it is of interest to decipher PPI for the understanding of molecular biology events. Experimental methods su
In order to remove the noise and irrelevant features which affect the protein prediction performance, the PCA was utilized for feature reduction before conducting the ensemble ELM classifier. Experimental results demonstrated that the proposed method performed significantly well in distinguishing interacting ...
here, we proposed a new method of reconstructing a yeast protein–protein interaction map that is solely based on the GO annotations. The method was validated
The overall model architectures for both the prediction of interaction sites (Figure 2A) and protein interaction prediction (Figure 2B) are very similar, as in both cases, the input consists of proteins and the output consists of a binary value. In particular, the initial processing sequence of...
Protein–protein interactions can be seen as a hierarchical process occurring at three related levels: proteins bind by means of specific domains, which in turn form interfaces through patches of residues. Detailed knowledge about which domains and resid
protein–protein interaction predictionprotein interaction prediction based on multidomain pairsExperimental Protein–Protein InteractionsPrediction of Protein–Protein InteractionsProtein Interaction Prediction Based on Multidomain PairsDomain Interaction Prediction Methods Summary...
Figure 7.7.Protein-protein interaction sites prediction using 3D structure with cons-PPISP: (a) input parameters, atomic coordinates, and chain information of the protein and (b) predicted binding sites; P: positive and N: negative. 7.1.6Energy-based approach for understanding the recognition mech...
The rapid growth of protein-protein interaction (PPI) data has led to the emergence of PPI network analysis. Despite advances in high-throughput techniques, the interactomes of several model organisms are still far from complete. Therefore, it is desirab
Proteins are the essential biological macromolecules required to perform nearly all biological processes, and cellular functions. Proteins rarely carry out their tasks in isolation but interact with other proteins (known as protein–protein interaction)