Protein–protein interactionFeature fusionL1-regularized logistic regressionGradient tree boostingMachine learningProtein鈥損rotein interactions (PPIs) are of great importance to understand genetic mechanisms, delineate disease pathogenesis, and guide drug design. With the increase of PPI data and development ...
NVDT A new computational method for protein-protein interaction and non-interaction predictions from the gene sequence Part 1:Datasets ---Positive and negative samples of each species. Each .xlsx file has two columns and several rows. Each row represents one protein pair (positive samples are int...
acid sequence information of domain combination pairs,and statistical calculating method as a supplementary.Thus,we can evaluate the interacting probability of all the possible domain combination pairs of each protein pair and preferable effect is obtained in the prediction of protein-protein interaction....
Protein-protein interactions are facilitated by a myriad of residue-residue contacts on the interacting proteins. Identifying the site of interaction in the protein is a key for deciphering its functional mechanisms, and is crucial for drug development. Many studies indicate that the compositions of ...
The heuristic technique has been applied to find the interface surface, which is active in a protein during interaction. Since finding an interface that takes part in the interaction is practically complicated, a similar interface can always be found. The heuristic technique is applied in such a ...
6) protein-protein interaction 蛋白质相互作用 1. Chemical cross linking technology used in the study of protein-protein interaction; 化学交联技术在蛋白质相互作用研究中的应用 2. The advance in research methods for large-scale protein-protein interactions; 大规模蛋白质相互作用研究方法进展 3. ...
Predict drug-protein interaction in cellular networking. Involved with many diseases such as cancer, diabetes, neurodegenerative, inflammatory and respiratory disorders, GPCRs (G-protein-coupled receptors) are th... Xuan,Xiao,Jian-Liang,... - 《Current Topics in Medicinal Chemistry》 被引量: 25...
Predictome采用了三种方法:chromosomal proximity、phylogenetic profiling 、domain fusion以及large-scale experimental screenings of protein–protein interaction data. Predictome 在可以获得。 2楼2013-02-23 21:37 回复 苍穹大仙 黃龍中威 13 介绍一个蛋白质的功能也许是最好的形容词汇与其他蛋白质相互作用(1)...
These features are useful for wide range of researchers to predict putative interaction sites and interacting proteins. 展开 关键词: Multiprotein Complexes Sequence Analysis, Protein Protein Interaction Mapping Binding Sites Structural Homology, Protein Dimerization Models, Molecular Internet Software ...
Hitherto, Protein-Protein Interaction (PPI) networks have been adopted by many computational methods to predict essential proteins. Most of the current approaches focus mainly on the topological structure of PPI networks. However, those methods relying solely on the PPI network have low detection ...