Protein–protein interaction networks are the networks of protein complexes formed by biochemical events and/or electrostatic forces and that serve a distinct biological function as a complex. The protein interactome describes the full repertoire of a biological system’s protein–protein interactions (PPI...
Moreover, protein-protein interaction networks have been used to discover novel protein function (Fionda et al., 2009) and to identify functional modules and conserved interaction patterns (Fionda and Palopoli, 2011). Some studies on the structure of the protein-protein interaction networks of ...
Protein function prediction using neighbor relativity in protein-protein interaction network. Comput. Biol. Chem. 43, 11-16.Moosavi, S., Rahgozar, M., Rahimi, A.: Protein function prediction using neighbor relativity in protein-protein interaction network. Comput. Biol. Chem. 43, DOI: 10.1016...
PROTEIN FUNCTION PREDICTION 采用了Seq2Vec作为backbone,和PPI一样,只是用protbert和ontoprotein替换了嵌入层。 划分为三个子集(BPO,MFO,和CCO),并对模型在每个子集上的表现分别进行评估。 感觉ProtBert预训练的时候做的是MLM,OntoProtein做了MLM和在GO的图谱上训练过,所以做这个GO的预测应该是肯定会有提升的。 Pro...
The study of protein-protein interactions is vital to the understanding of how proteins function within the cell. Publication of the human genome and proteomics-based protein profiling studies catalyzed resurgence in protein ...
Proteins are the essential biological macromolecules required to perform nearly all biological processes, and cellular functions. Proteins rarely carry out their tasks in isolation but interact with other proteins (known as protein–protein interaction)
to gain deeper insights into a target’s structure and function. When it comes to the investigation, IP, Co-IP and pull-down assays have become invaluable tools, which are built upon the affinity-based immobilization of a “bait” protein on a solid support, mostly magnetic or agarose beads...
versestructuresandfunction,suchasproteinkinases, kinesins,proteasomecomponents,transcriptionfactors, etc.[1].Similarresultshadbeenobtainedforindividual protein-mRNApairs[2-6],butourworkandthatof othersdemonstratedthatthisphenomenoncouldbead- dressedatthegenome-widelevelandinanunbiasedman- ...
Protein- protein Interaction Extraction Based on Convex Combination Kernel Function[J]. Journal of Computer and Communications,2013,1( 5) : 9-13.Chen Peng,Guo Jianyi,Yu Zhengtao,et al.Proteinprotein Interaction Extraction Based on Convex Combination Kernel Function[J].Journal of Computer and ...
Determining protein partners is an essential step toward understanding protein function and identifying relevant biological pathways. Many methods exist for investigating protein–protein interactions. The pull-down assay is an in vitro technique used to detect physical interactions between two or more prot...