A single pair of enzymes — O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) — controls the dynamic cycling of this PTM. Potential mechanisms that enable a single OGT enzyme to recognize hundreds of protein substrates include substrate-specific interactions with the tetratricopeptide repeat (TPR)...
O-GlcNAcylation is a post-translational modification of proteins that involves the addition of O-GlcNAc to serine or threonine residues of nuclear or cytoplasmic proteins, catalyzed by O-GlcNAc transferase (OGT). This modification is highly dynamic and can be reversed by O-...
Product Name:protein O-GlcNAc transferase Synonyms:protein O-GlcNAc transferase CAS: MF: MW:0 EINECS: Mol File:Mol File Browse by Nationality Suppliers>China suppliers United States (2)Member(2)All (2) Recommend You Select Member Companies ...
O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e. O-GlcNAc transferase (OGT) and protein O-GlcNAcase (OGA). Protein O-GlcN
In this study, we show that pharmacological inhibition or siRNA-mediated reduction of O-GlcNAc transferase (OGT), the enzyme responsible for glycosylation of intracellular proteins, increases expression of p21 in both p53-dependent and p53-independent manners in nontransformed and cancer cells. In ...
protein O-GlcNAc transferase 中文名: 中文别名: CBNumber: CB67250323 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商2 protein O-GlcNAc transferase化学性质 安全信息 protein O-GlcNAc transferase性质、用途与生产工艺 protein O-GlcNAc transferase上下游产品信息 ...
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The essential mammalian enzyme O-GlcNAc Transferase (OGT) is uniquely responsible for transferring N-acetylglucosamine to over a thousand nuclear and cytoplasmic proteins, yet there is no known consensus sequence and it remains unclear how OGT recognizes its substrates. To address this question, we de...
Insights into the regulation of O-GlcNAc transferase and protein GlcNAcylation. In response to different environmental cues, nuclear and cytoplasmic proteins are posttranslationally modified on serine and threonine residues by the mono... WD Cheung - The Johns Hopkins University.; 被引量: 0发表: 200...
GlcNAc can be added to proteins by O-GlcNAc transferase (OGT) to regulate protein activity. In the embryos of diabetic mice, OGT is highly activated in association with increases in global protein O-GlcNAcylation. In neural stem cells in vitro, high glucose elevates O-GlcNAcylation and reactive...