O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e. O-GlcNAc transferase (OGT) and protein O-GlcNAcase (OGA). Protein O-GlcNAcylation mainly occurs in the cytoplasm, ...
O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e.O-GlcNAc transferase (OGT) and proteinO-GlcNAcase (OGA). ProteinO-GlcNAcylation mainly occurs in the cytoplasm, nucleus...
近日,周军教授课题组在Protein & Cell在线发表题为O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis的论文,揭示了O-GlcNAc在纤毛稳态调控中的新机制【3】。 在本项研究中,周军教授课题组进一步研究了O-GlcNAc修饰对纤毛的调控及相关机制。发现在小鼠体内敲低O-GlcN...
A single pair of enzymes — O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) — controls the dynamic cycling of this PTM. Potential mechanisms that enable a single OGT enzyme to recognize hundreds of protein substrates include substrate-specific interactions with the tetratricopeptide repeat (TPR)...
protein O-GlcNAc transferase information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors, which is controlled by two highly conserved enzymes, i.e. O-GlcNAc transferase (OGT) and protein O-GlcNAcase (OGA). Protein O-GlcN
O-linked β-N-acetylglucosamine (O-GlcNAc) in intestinal epithelial cells. Via FOXO1 O-GlcNAcylation, O-GlcNAc transferase (OGT) suppresses expression of the lineage-specifying transcription factor Neurogenin 3 and, thus, L cell differentiation from enteroendocrine progenitors. Intestinal epithelial ...
O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins by β-N-acetylglucosamine (GlcNAc). The dynamic addition and removal of O-GlcNAc groups to and from proteins are catalyzed by O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) and β-N-acetylgl...
O-GlcNAc transferase (OGT) is responsible for the addition of this mark whereas O-GlcNAcase (OGA) removes it from proteins (17, 29). Discovered initially by Hart and Torres in the early 1980s (30), protein O-GlcNAcylation has garnered much attention since then due to its role in various...
3 Protein O-GlcNAcylation is catalyzed by two enzymes: O-GlcNAc transferase (OGT)4, 5, 6 and β-D-N-acetylglucosaminidase (O-GlcNAcase/OGA7), which adds O-GlcNAc to target residues and removes O-GlcNAc, respectively. O-GlcNAcylation plays essential roles in many physiological/pathological ...