Pohl,S. Storch.Molecular analysis of the GlcNac-1-phosphotransferase[J]. Journal of Inherited Metabolic Disease .2008(2)Braulke T, Pohl S, Storch S. Molecular analysis of the GlcNac-1- phosphotransferase. J Inherit Metab Dis 2008 (31): 253-57....
Key to this pathway is N-acetylglucosamine (GlcNAc)-1-phosphotransferase (PTase) that selectively adds GlcNAc-phosphate (P) to mannose residues of hydrolases. Human PTase is an α2β2γ2 heterohexamer with a catalytic core and several peripheral domains that recognize and bind substrates. Here ...
GlcNAc-1-phosphotransferase (GNPT) catalyzes the initial step in the formation of the mannose-6-phosphate tag that labels ~60 lysosomal proteins for transport. Mutations in GNPT cause lysosomal storage disorders such as mucolipidoses. However, the molecular mechanism of GNPT remains unclear. Mammal...
ChemicalBook 致力于为化学行业用户提供UDP-GlcNAc - Ser-protein N-acetylglucosamine-1-phosphotransferase的性质、化学式、分子式、比重、密度,同时也包括UDP-GlcNAc - Ser-protein N-acetylglucosamine-1-phosphotransferase的沸点、熔点、MSDS、用途、作用、毒性、价格
英文别名: UDP-GlcNAc - Ser-protein N-acetylglucosamine-1-phosphotransferase中文名: 中文别名: CBNumber: CB21363333 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 0 UDP-GlcNAc - Ser-protein N-acetylglucosamine-1-phosphotransferase化学性质...
Phosphoglycosylation catalyzed by UDP-GlcNAc:Ser-protein N-acetylglucosamine-1-phosphotransferase (Ser:GlcNAc phosphotransferase) adds GlcNAcalpha-1-P to peptidyl-Ser of selected Dictyostelium discoideum proteins. Lysosomal cysteine proteinase (CP), proteinase-1(CP7), is the major phosphoglycosylated protein...
GlcNAc-1-Phosphotransferase (UDP-GlcNAc; lysosomal enzyme N-acetylglu- cosamine-1-phosphotransferase; EC number 2.7.8.17) catalyzes the transfer of GlcNAc-1-phosphate from UDP-GlcNAc to the C-6 oxygen of selected mannose residues in high-mannose-type N-glycan. The product, mannose 6-phosphate ...
UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-PT) is an α2 β2 γ2 hexamer that mediates the initial step in the formation of the mannose 6-phosphate targeting signal on newly synthesized lysosomal acid hydrolases. The GNPTAB gene encodes the 1256 amino acid ...
Structure of the human GlcNAc-1-phosphotransferase αβ subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylationdoi:10.1038/s41594-022-00748-0Vertebrates use the mannose 6-phosphate (M6P)-recognition system to deliver lysosomal hydrolases to lysosomes. Key to this pathway is-...
GlcNAc-1-phosphotransferase catalyzes the initial step in the formation of the mannose-6-phosphate tag that labels ~60 lysosomal proteins for transport.Mudoi:10.2139/ssrn.3844731Du, ShuoWang, GuopengZhang, ZhiyingMa, ChengyingGao, NingXiao, Junyu...