Learn what is a protein molecule and what is involved at each level of protein molecular structure. Also see protein molecule examples and their...
(―S―S―) that results when a hydrogen atom is removed from the mercapto group of each of the cysteines. Disulfide bonds are important in protein structure because they allow the linkage of two different parts of a protein molecule to—and thus the formation of loops in—the otherwise ...
After the first binding event of a bivalent molecule, subsequent binding events are controlled by the effective concentration and the monovalent KD analogous to intramolecular binding. The effective concentration thus controls the population of singly bound protein from which the full dissociation must ...
In E. coli, MutL was considered as an intermediate molecule linking MutS and MutH proteins and mediating the interaction between the mismatch recognition machinery and the strand-discrimination and excision machineries [15]. MutL in E. coli has no endonucleolytic activity. Such activity has likely...
protein–protein interactions is challenging, owing to issues such as the general lack of small-molecule starting points for drug design, the typical flatness of the interface, the difficulty of distinguishing real from artefactual binding, and the size and character of typical small-molecule ...
Proteins are molecular machines and to understand how they work, we need to understand how they move. New pump-probe time-resolved X-ray diffraction methods open up ways to initiate and observe protein motions with atomistic detail in crystals on biologi
Therefore, if it is suspected that these substances might interfere with the function of the molecule of interest, pre-dialyze the membrane or device with ultrapure water or buffer for 30 minutes before adding the sample. Regenerated ...
(or disordered protein regions) exhibit dynamic and heterogeneous conformations that do not display similar, temporally stable small molecule binding sites. However, despite the lack of temporally stable feature, many disordered proteins/regions interact with macromolecular partners through the process of ...
as well as novel cyclic non-natural amino acid (nnAA) peptides with small-molecule drug-like properties. Finally, we summarize recent advances demonstrating the potential for integrating these cell-free display-based discovery platforms with cell-free protein synthesis for cGMP manufacture of clinical...
(Skorupa et al., 2001). MBP, the myelin essential structural protein, has been called the executive molecule of myelin (Boggs, 2006). The important role of MBP is to maintain the stability of myelin structure and function. Through the vertical membrane coupling MBP closes the different layers...