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(―S―S―) that results when a hydrogen atom is removed from the mercapto group of each of the cysteines. Disulfide bonds are important in protein structure because they allow the linkage of two different parts of a protein molecule to—and thus the formation of loops in—the otherwise ...
After the first binding event of a bivalent molecule, subsequent binding events are controlled by the effective concentration and the monovalent KD analogous to intramolecular binding. The effective concentration thus controls the population of singly bound protein from which the full dissociation must ...
Fig. 2.(A) Crystal structure of PKA-C in the open state (PDB code 1CTP). (B) Superposition of crystal structures of PKA-C in its open (red, PDB code 1CTP), intermediate (blue, PDB code 1BKX), and closed (yellow, PDB code 1ATP) states. The ATP molecule that binds in the ac...
However, as a molecule's molecular weight increases, the rate of movement in solution decreases along with the chance of diffusion through the membrane - even if it the molecule is small enough to pass through the pores. The rate...
To overcome these limitations, we developed a simple structure-based statistical mechanical model, named the WSME-L model (L denotes linker), which can introduce virtual linkers corresponding to nonlocal interactions anywhere in a protein molecule (Fig. 1c, e). This model improves the prediction ...
S2). A plot of the intensity-based FRET efficiency versus the donor fluorescence lifetime (E-τ plot) indicates whether the molecule is static or dynamic on the ns-ms timescale. Dynamic samples will deviate from the static FRET-line (black line, Fig. 2b)30. For all three constructs, ...
Single-Molecule Real-Time (SMRT) full-length RNA-sequencing reveals novel and distinct mRNA isoforms in human bone marrow cell subpopulations. Genes. 2019;10:17. Article Google Scholar Weatheritt RJ, Sterne-Weiler T, Blencowe BJ. The ribosome-engaged landscape of alternative splicing. Nat ...
to different domains, 2) Accessible Surface Area (ASA), a method for detecting the buried region of a protein that is detached from a solvent when forming multimers or complexes, and 3) the Voronoi diagram, a computational geometry method that uses a mathematical definition of interface regions...
Many automated systems have shown reasonable improvements since they have successfully captured the information of a single molecule or of neighbouring residues involving short-range (local) interactions. However, at the same time, their limitations in the exploitation of information from long-range (...