(A) Most proteins currently used as folding models are marginally stable (black), meaning that their folded lifetime (t1/2) is short. Lifetime can be increased in two ways. The native structure can be stabilized thermodynamically, increasing the energetic difference between the denatured...
Though scaffolds are not stringently defined in meaning, they are known to interact with numerous components of a signaling pathway, binding and bridging them into distinct and functional complexes. They control signal transduction and assist the localization of pathway components (organized in complexes...
Protein in our diets comes from both animal and vegetable sources. Most animal sources (meat, milk, eggs) provide what's called "complete protein", meaning that they contain all of the essential amino acids. Vegetable sources usually are low on or missing certain essential amino acids. For ex...
(Hunter et al., 2010). Another advantage is the very high insect species specificity of RNAi molecules, meaning only non-target arthropods closely related to the pest taxonomically would be negatively affected (Huesing et al., 2009). This specificity also means that non-target organism testing...
at low strain means we can form gels within a syringe for long-term room temperature storage, followed by release through a syringe filter; the essentially insoluble extended supramolecular network will be trapped in the syringe filter, meaning that only the pure protein is released (Fig.1f,g)...
Structural analyses presented in Fig. 4 consider residues associated with symmetry axes along which fibres can grow, meaning that their nDp values are lowest with respect to those axes. This notion is illustrated with the lower structures, where nDp values of red-coloured residues are smaller with...
A significant number of proteins have been shown to be intrinsically disordered, meaning that they lack a fixed 3 D structure or contain regions that do not posses a well defined 3 D structure. It has also been proven that a protein's disorder content is related to its function. We have ...
investigated in this study are the UPF3A and UPF3B proteins. These two proteins are paralogous, meaning they arose through duplication in the genome and have persisted throughout evolution. Both UPF3A and UPF3B are ubiquitously expressed, but exhibit tissue-specific differences in their level...
The latter would be more discriminative in capturing longer patterns, while maintaining lower sparsity (i.e. less zeros) in the feature space. Another possible variation is k-mer mirror symmetry, meaning that AA k-mers such as “PG” and “GP” are treated as the same feature, yielding a...
Unless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by a person skilled in the art to which this invention belongs. The following references provide one of skill with a general definition of many of the terms used in this invention: Singlet...