(A) Most proteins currently used as folding models are marginally stable (black), meaning that their folded lifetime (t1/2) is short. Lifetime can be increased in two ways. The native structure can be stabilized thermodynamically, increasing the energetic difference between the denatured...
(Hunter et al., 2010). Another advantage is the very high insect species specificity of RNAi molecules, meaning only non-target arthropods closely related to the pest taxonomically would be negatively affected (Huesing et al., 2009). This specificity also means that non-target organism testing...
Protein in our diets comes from both animal and vegetable sources. Most animal sources (meat, milk, eggs) provide what's called "complete protein", meaning that they contain all of the essential amino acids. Vegetable sources usually are low on or missing certain essential amino acids. For ex...
These interaction types do not have any pre-defined meaning, but rather the model learns to assign a meaning to each type. The structure of the model is presented in Fig. 1. The code is freely available at https://github.com/juexinwang/NRI-MD. This model is formalized as a variational...
at low strain means we can form gels within a syringe for long-term room temperature storage, followed by release through a syringe filter; the essentially insoluble extended supramolecular network will be trapped in the syringe filter, meaning that only the pure protein is released (Fig.1f,g)...
It was also found that purified protein was unable to catalyze citrate production alone, meaning that other proteins were involved in rescue in vivo. Protein partners were investigated for synGltA, and two proteins were found to be necessary for the rescue of ∆gltA by synGltA. Together,...
A significant number of proteins have been shown to be intrinsically disordered, meaning that they lack a fixed 3 D structure or contain regions that do not posses a well defined 3 D structure. It has also been proven that a protein's disorder content is related to its function. We have ...
in coordination chemistry. Such approaches clarify the origins, inter alia, of many low energies of protein denaturation, which lie in the range of only a few kcal mol−1, and the difficulties in finding the structures of proteins in the multiple substates postulated within complex kinetic ...
“CRP” means “Catabolite regulator protein”. “CRP” is often referred in the art as “cyclic AMP receptor protein”, which has the synonymous meaning. CRP is a regulator protein controlled by cyclic AMP (cAMP) which mediates the activation of catabolic operons such as the L-rhamnose opero...
Unless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by a person skilled in the art to which this invention belongs. The following references provide one of skill with a general definition of many of the terms used in this invention: Singlet...