Sign in to download full-size image Figure 3.Examples of diversity among protein folding mechanisms.(A)Most proteins currently used as folding models are marginally stable (black), meaning that their folded lifetime (t1/2) is short. Lifetime can be increased in two ways. The native...
Proteins are polymers, and yet the language used in describing their thermodynamics and kinetics is most often that of small molecules. Using the terminology and mathematical descriptions of small molecules impedes understanding why proteins have evolved to be big in comparison. Many properties of the ...
Protein in our diets comes from both animal and vegetable sources. Most animal sources (meat, milk, eggs) provide what's called "complete protein", meaning that they contain all of the essential amino acids. Vegetable sources usually are low on or missing certain essential amino acids. For ex...
Protein in our diets comes from both animal and vegetable sources. Most animal sources (meat, milk, eggs) provide what's called "complete protein", meaning that they contain all of the essential amino acids. Vegetable sources usually are low on or missing certain essential amino acids. For ex...
And comparing the local shape information of two proteins leads us to find some local shape similarity for some pairs of proteins whose structure similarity is difficult to evaluate by traditional comparison methods. The biological meaning of local shape similarity remains unclear. 展开 ...
However, the lack of protons on the side-chains leads to a dramatic reduction in the number of NOEs, meaning that there will generally be insufficient distance information for a high-resolution structure determination. This problem is more fundamentally limiting for helical membrane proteins, where ...
These interaction types do not have any pre-defined meaning, but rather the model learns to assign a meaning to each type. The structure of the model is presented in Fig. 1. The code is freely available at https://github.com/juexinwang/NRI-MD. This model is formalized as a variational...
Structural analyses presented in Fig. 4 consider residues associated with symmetry axes along which fibres can grow, meaning that their nDp values are lowest with respect to those axes. This notion is illustrated with the lower structures, where nDp values of red-coloured residues are smaller with...
Genomic analysis of intrinsically disordered proteins in cereals: From mining to meaningCerealsDatabasesDisordered proteinsIDPIntrinsically disordered proteins (IDPs) are highly abundant in eukaryotic proteomes and involved in key biological and cellular processes. Although some resources of disordered protein ...
, indicating that, unlike for the antiviral activity, the antimicrobial activity of RNF213 requires ISG15. In contrast, overexpressed HA-ISG15 still counteractedListeriain RNF213 knockout (Fig.7d) or knockdown cells (Supplementary Fig.9e), meaning that ISG15 also harbors antimicrobial activity ...