"MiRNAs are small RNA molecules that do not encode proteins like most genes do, yet they play essential roles in gene regulation by repressing the expression of target genes," added Dr Tian. FromScience Daily Blocking it and cutting off the energy and protein building blocks it provides has ...
A poorly defined or undefined protein transition can be used to justify specific actions or solutions without adequately addressing the core challenges mentioned in ‘The three challenges protein transition aims to address’ in Results18. A clear definition is essential to ensure that the objectives of...
Protein synthesisis an energy intensive process requiring about 10 translation factors in addition to aminoacyl-tRNAs and the ribosome. The process ofprotein synthesiscan be divided into four stages: (1) initiation, (2) elongation, (3) termination, and (4) recycling (Figure 1). During the init...
Insertions/deletions (indels) in protein sequences are useful as drug targets, protein structure predictors, species diagnostics and evolutionary markers. However there is limited understanding of indel evolutionary patterns. We sought to characterize indel patterns focusing first on the major groups of ...
Shi, Yigong Westlake University, Hangzhou, China Citations 40,752 h-index 105 Publications 82 Liu, Lifeng Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China Citations 37,174 h-index 86 Publications 232
a, Operational definition of sb-pQTLs: an SNP needs to meet both of the following two criteria to be declared a sb-pQTL. First, it is a pQTL in males or females or both at FDR < 0.05. Second, it has a significant genotype-by-sex interaction in protein expression at FDR <...
In this section, we introduce some key definitions that will be used in our model and formulas.. Definition 1 (Complex Interaction Graph [2,35]) For an protein-ligand complex, letVL:={a1L,a2L,…,anL}be the ligand atom set,VP:={a1P,a2P,…,amP}be the protein atom set. We define ...
to different domains, 2) Accessible Surface Area (ASA), a method for detecting the buried region of a protein that is detached from a solvent when forming multimers or complexes, and 3) the Voronoi diagram, a computational geometry method that uses a mathematical definition of interface regions...
[15,16]. If the change in the Gibbs free energy is negative, binding reaction is a spontaneous process otherwise non spontaneous process[11]. It also determines the stability of protein-ligand complex and the binding affinity between the two moieties. Gibbs free energy (ΔG) is dependent on...
In subject area:Neuroscience Protein biosynthesis refers to the process of creating proteins within a cell, involving the translation of genetic information into functional proteins through the synthesis of amino acids. AI generated definition based on:Human Biochemistry,2018 ...