Chemical probes are selective small-molecule modulators, usually inhibitors, of their target protein’s function, that can be used in cell or even animal studies to interrogate the functions of their target proteins. Cheryl Arrowsmith, the leader of a new initiative called Target 2035, which seeks...
Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol. 2000;2:E65–7. Article CAS PubMed Google Scholar Indovina P, Pentimalli F, Casini N, Vocca I, Giordano A. RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy. Oncotarget. ...
Opportunities and challenges in design and optimization of protein function Dina Listov, Casper A. Goverde, Bruno E. Correia & Sarel Jacob Fleishman Nat Rev Mol Cell Biol (2024) The State-of-the-Art Overview to Application of Deep Learning in Accurate Protein Design and Structure Prediction Saber...
2023年7月14日，王磊研究员团队在Protein & Cell发表题为SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic的文章。该文章通过超分辨成像、细胞分级、蛋白质稳定性及表观修饰检测等多种手段论证了ORF8是一个内质网腔定位蛋白，不具有核定位和模拟组蛋白的功能，对ORF8调控宿主细胞表观遗传...
3 Canonical protein kinase signalling in neuroblastoma Unlike enzymes in metabolic pathways that are commissioned to turnover large amounts of substrate, protein kinases have evolved to specifically function as molecular on/off “switches” and not efficient catalysts, largely by virtue of their internal...
Gaudel C, Nongonierma AB, Maher S, Flynn S, Murray BA, Kelly PM, Krause M, FitzGerald RJ, Newsholme P (2013) A whey protein hydrolysate promotes insulinotropic activity in a clonal pancreatic β−cell line and enhances glycemic function in ob/ob mice. J Nutr 143:1109–1114 Google Schol...
37 Inhibiting the LAG-3 and PD-1 pathways could improve T-cell function in ovarian cancer.66 In hepatocellular carcinoma, elevated expression of LAG-3 on TILs has been observed.67 In gastric cancer, positive PD-1 and LAG-3 expression was elevated on CD4-positive and CD8-positive T cells,...
and they carry out important and diverse functional roles in the cell directly facilitated by their lack of structure. Despite their prevalence and critical roles in function and disease, IDRs do not fit neatly in the structure-function paradigm and remain outside the capabilities of structure-based...
According to researchers, many transmembrane proteins act as gateways for the movement of specific substances across a biological membrane, and some of them receive or transmit cell signals, so many drugs are designed to target transmembrane proteins and alter their function....
We also show that DUET is required for proper microtubule organization during meiosis II, independently of its function in meiosis I. Remarkably, DUET protein shows stage-specific expression, confined to diplotene. We identify two genes TDM1 and JAS with critical functions in cell cycle transitions...