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Phospho-tau expression colocalized with doublecortin but not with glial fibrillary acidic protein, Ki67 or calbindin. The same was observed in the subventricular zone. Tau knockout mice did not show a significant decrease in the number of doublecortin-positive cells, although a deficit in migration...
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Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between...
Bimolecular Fluorescence complementation; lighting-up Tau-Tau interaction in living cells. PLoS ONE 8, e81682 (2013). Article ADS PubMed PubMed Central Google Scholar Bertram, L., McQueen, M. B., Mullin, K., Blacker, D. & Tanzi, R. E. Systematic meta-analyses of Alzheimer disease ...
3b). To avoid global inhibition of protein synthesis, we employed cells in which the expression of TauRD-Y is controlled with a Tet-regulated promoter (Tet-TauRD-Y and Tet-TauRD-Y* cells)39. The addition of doxycycline resulted in the clearance of TauRD-Y inclusions and insoluble TauRD...