Tau protein function in axonal formation. Neurochem Res 2000; 25: 37-42.Paglini G, Peris L, Mascotti F, Quiroga S, Caceres A. 2000. Tau protein function in axonal formation. Neurochem Res 25:37-42.Paglini G, Peris L, Mascotti F, Quiroga S, Caceres A. Tau protein function in ...
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Protein expression was induced by addition of IPTG to 0.5 mM. Bacterial cells were harvested by centrifugation then resuspended in ice-cold lysis buffer (20 mM MES, 1 mM EGTA, 0.2 mM MgCl2, 5 mM DTT, 1 mM PMSF, 1 mg/mL lysozyme, 10 µg/mL DNAse, pH 6.8) ...
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Tau protein aggregation in the frontal and entorhinal cortices as a function of aging 1 The abnormal accumulation of tau protein is increasingly recognized as the neuropathological hallmark of a number of dementing illness in which frontotem... W Yang,LC Ang,MJ Strong - 《Brain Res Dev Brain...
含缬氨酸蛋白(valosin-containing protein,简称VCP)是一种AAA+蛋白,其可以利用ATP水解所产生的能量来打开底物,以协助对大分子复合物的降解【5】。AAA+指一类与多种细胞活性相关的腺苷三磷酸酶(ATPase)【6】。 有研究表明,VCP蛋白表达于中心神经系统的多个细胞类型中,包括额叶、大脑皮层、质脊髓等神经细胞;VCP基因也...
Association of G proteinヽoupled receptor kinases with tau pathology in Alzheimer's disease: Developing topics These results provide a foundation for future mechanistic studies addressing the putative role of GRKs in tau physiology and pathology.doi:10.1002/alz.047492Thais Rafael GuimaraesEric SwansonJul...
为了更深入了解Tau引起的PSD凝聚物动力学减缓的因素,研究者利用核磁共振(nuclear magnetic resonance;以下简称NMR)波谱法检测到PSD-95引发了Tau信号峰(signal peaks)的减弱,特别是在微管结合序列(microtubule-binding repeats)中的Q244到N255(R1)、V275到S285(R2)和G304到D314(R2/R3)区域,这些地方PSD-95引发的...
The relatively limited duration of follow-up, even if it is equal to or greater than most of the studies published to date, also constitutes a limitation of this study, in particular for the longer-term assessment of the impact of changes in tau protein, some of which may occur later. ...
The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the ex