Objective To investigate whether increasing protein intake to 1.3 g/kg/d in older adults with physical function limitations and usual protein intake within the RDA improves lean body mass (LBM), muscle performance, physical function, fatigue, and well-being and augments LBM response to a muscle ...
a, Causal genes with sb-pQTLs (n = 12). Among these, three also had sex-biased protein expression:CNTN2,ERLEC1andGIGYF2(in bold). Detailed results are in Supplementary Table18.b, Causal proteins in females only (n = 11). Among these 11 proteins, three also had sex-biased ...
Sparks of function by de novo protein design Alexander E. Chu, Tianyu Lu & Po-Ssu Huang Nat Biotechnol 42, 203–215 (2024) • poster A Survey of Generative AI for De Novo Drug Design: New Frontiers in Molecule and Protein Generation Xiangru Tang, Howard Dai, Elizabeth Knight, Fang Wu...
Protein - Muscle, Structure, Function: The total amount of muscle proteins in mammals, including humans, exceeds that of any other protein. About 40 percent of the body weight of a healthy human adult weighing about 70 kilograms (150 pounds) is muscle, w
Predicting the structure of interacting protein chains is a fundamental step towards understanding protein function. Unfortunately, no computational method can produce accurate structures of protein complexes. AlphaFold2, has shown unprecedented levels of accuracy in modelling single chain protein structures. ...
We tested the hypothesis that concentrations of non-protein-bound (free) and loosely bound (bioavailable) sex hormones are associated with cognitive function in older women. We measured cognitive performance with a modified mini mental status examination (mMMSE) at baseline (1986–88) and 6 years...
There are about 20 different amino acids that occur naturally in proteins. Proteins of similar function have similar amino acid composition and sequence. Although it is not yet possible to explain all of the functions of a protein from its amino acid sequence, established correlations between ...
gondii, but also a regulatory molecule that participates in gene activation and protein function. Lysine lactylation (Kla) is a type of post-translational modifications (PTMs) that has been recently associated with chromatin remodeling; however, Kla of histone and non-histone proteins has not yet...
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological processes. Although the classical PTMs, such as phosphorylation, acetylation, ubiquitination and methylation, have be...
(bottom inside-of-protein view). In the bottom view, a group of chemically relevant descriptors, instead of the protein sequences, are used to better capture the structure-function relationship of the protein. HIGH-PPI examines both outside-of-protein and inside-of-protein of the human ...