7) From the results mentioned above it became clear that among the various patterns of serum protein detected by the disc-electrophoresis in acrylamide gels, the B-, C-, F-, and J-bands were closely correlated with the egg-laying function of the females and were controlled by the sex ...
During the exploration of the function of WFS1 in pancreatic β-cells, we found an interesting phenomenon in which the distribution of proinsulin was largely different in the scrambled (control) INS1 cells compared withWfs1knockdown INS1 cells (shWfs1) with stable expression of a short hairpin ...
Sparks of function by de novo protein design Alexander E. Chu, Tianyu Lu & Po-Ssu Huang Nat Biotechnol 42, 203–215 (2024) • poster A Survey of Generative AI for De Novo Drug Design: New Frontiers in Molecule and Protein Generation Xiangru Tang, Howard Dai, Elizabeth Knight, Fang Wu...
Classes of enzymes (E1, E2 and E3) function in specifically ubiquitylating proteins within the cell, thus targeting these clients for destruction by the proteasome. Autophagy A form of cellular catabolism that is responsible for the removal of large cellular components (for instance, protein ...
Diffusion Models in Bioinformatics: A New Wave of Deep Learning Revolution in Action. Zhiye Guo, Jian Liu, Yanli Wang, Mengrui Chen, Duolin Wang, Dong Xu, Jianlin Cheng. Preprint, February 2023. [arxiv] From sequence to function through structure: deep learning for protein design. Noelia Fer...
fibres with matrix components via receptors on the cell membrane can influence the organization ofmembranemolecules as well as matrix components and can modify the shape and function of the cytoskeleton. Changes in the cytoskeleton can lead to changes in cell shape, movement,metabolism, anddevelopment...
In this study, we analyze the scaling of intrinsic disorder in eukaryotic proteins and investigate the presence of length-dependent functions attributed to proteins containing long disordered regions. 展开 关键词: Intrinsically disordered protein Protein function Eukaryotic proteome ...
The MmedCSP3 may be involved in locating host insects. Our data provide a base for further investigating the physiological roles of OBPs and CSPs in M. mediator, and extend the function of MmedCSP3 in chemoreception of M. mediator. 展开 ...
A role for the P-body component GW182 in microRNA function. Nature Cell Biol. 7, 1161–1166 (2005). Article CAS Google Scholar Rehwinkel, J., Behm-Ansmant, I., Gatfield, D. & Izaurralde, E. A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene...
mRNA-binding protein Fmrp localizes in ciliary central lumen and appears to function in mRNA delivery into the cilia. Its depletion by RNAi impairs ciliary local translation and induces multicilia degeneration. Expression of exogenous Fmrp, but not an isoform tethered to mitochondria, rescues the ...