Dyson HJ, Wright PE: Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol. 2005, 6 (3): 197-208. CAS PubMed Google Scholar Uversky VN, Oldfield CJ, Dunker AK: Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling. J Mol ...
To address these possibilities, the relationship between novel fold structures and their functions need to be studied. We tested whether AlphaFold2 (ref. 33) can predict the designed structures with novel αβ-folds from their amino acid sequences, using the template structure database as it ...
E. Intrinsically unstructured proteins and their functions. Nat. Rev. Mol. Cell Biol. 6, 197–208 (2005). CAS PubMed Google Scholar Cai, S. & Singh, B. R. Identification of beta-turn and random coil amide III infrared bands for secondary structure estimation of proteins. Biophys. Chem...
This review aims to discuss the advanced colloids developed by the interaction of the protein with various biopolymers and their potential application in the food sector. 2. Functional colloids produced by protein-biopolymer interactions Protein biopolymer interaction is an area of interest for researchers...
Mitochondria are essential for cells to convert energy from organic matter into a usable form. Proteins contained in mitochondria play an important role in main functions such as aerobic respiration, maintaining mitochondrial structure and regulating metabolism. ...
We take the functions of two proteins to be similar if both their functional annotations fall into the same class. Based on this classification, we measure the correlation between functional annotations of interacting proteins by mutual information. For conserved interactions, this is nearly 20-times...
Liu Haiyan and Prof. Chen Quan from the University of Science and Technology of China (USTC) published a study regarding protein design in the scientific journal Nature on February 10, Beijing time. Proteins are the foundation of life and the main executors of cellular functions, with their ...
ProtCAD ProtCAD is a suite of tools for the design and engineering of novel protein structures, sequences, and functions. It allows users to build and manipulate complex protein structures, generate and evaluate sequence libraries, and simulate mutational effects. ProtCAD is a suite of tools for...
Milk proteins and milk protein-derived peptides have been widely studied for their health enhancing properties. This chapter presents the updated scientific knowledge on the bioactive properties of milk protein-derived peptides. The different bioactive p
Similar to words in natural language, a gene can confer different functions29 depending on its context30, and many genes confer similar functions (i.e. convergent evolution31, remote homology32). We used gLM to generate 1280-feature contextualized protein embeddings at inference time (Fig. 1B)...