Here we studied thioredoxin-like protein 1 (TXNL1) which is a 26S proteasome component directly involved with the regulatory particle non-ATPase 11 (rpn11), a subunit of the 26S proteasome, translation elongation factor 1A (eEF1A1) [5], and transfers misfolded proteins to degradation [6,7...
1b). Importantly, as these cells differentiate, they also significantly increase their expression of ACLP and collagen I (Fig. 1c). Figure 1 ACLP promotes adventitial Sca1 cell differentiation into myofibroblast-like cells. Sca1 cells were isolated from mouse aorta adventitia and cultured on ...
Additionally, EFL1 also tests the functionality of the newly synthesized 60S subunits before they enter the pool of translating ribosomes by means of a translocation-like activity (11). As a GTPase, EFL1 has a conserved G-domain in domain 1 composed of the five structural motifs (G1–G5)...
which requires the coordinated activity of actin-binding proteins (ABP) [28,30,39,42]. To date, only few ABP have been implicated in the formation of filopodia-like spines including mouse diaphanous 2 (mDia2), a formin family member that nucleates unbranched F-actin, and the elongation fac...
We observed relationships between mRNA and protein variability that are consistent with earlier observations where cells employ mechanisms to either reduce or amplify intra- and inter-cell protein expression variability introduced by burst-like/noisy mRNA transcription25. While protein globally exhibits lower...
(1, B): Effect of fluoxetine (FLX) on time required to reach platform of psychologically stressed protein malnourished mice. a: significantly different from normally- fed normal control i.p. at p< 0.05 b: significantly different from normally- fed escapable control i.p. at p< 0.05 B: ...
Figure 1 Epac2−/−mice exhibit anxiety- and depressive-like behaviors. (a) Results of the open field test in wild-type (WT) and Epac2−/−mice. The time spent in the center area and the distance moved during a 1-h period in the open field were measured (for time spent in ...
Domains like the RNA recognition motif were found equally in both phases. A total of 35% of C. oncophora peptides and O. ostertagi peptides could be associated with GO terms categorized as ‘biological process’, ‘cellular component’, and/or ‘molecular function’ (Table 1 and Additional ...
In all experiments, experimenters were blinded to the genotype during image acquisition and analysis, including the planned segregation of thin and mushroom-like spines. 3. Results 3.1. Enrichment of myc-CAP1 in dendritic spines In a previous study (Heinze et al., 2022), by exploiting a green...
This discrepancy can be explained by the heterogeneous material of the samples and connected abiotic processes like pre- cipitation of sulfide with iron ions stemming from The ISME Journal the sediment. Such effects were also observed in previous studies (Vogt et al., 2007). The carbon isotope...