Plasma protein binding and drug interactionsD'Arcy, P.FMcElnay, James
When two drugs that both bind to albumin are given simultaneously, they may compete for availablebinding sites, increasing the free fraction of the other. Although this displacement from plasma proteins often is cited as an important mechanism by which drug interactions can be mediated, this is no...
Therefore, we hypothesized that RAL disposition may be effected by protein binding, which may need to be considered when interpreting in vitro cellular permeation data. Methods. RAL membrane permeation was investigated using the PAMPA model, which are free of drug transporters and which models the ...
TTGCN 预测新的 DTI 为了评估其有效性,TTGCN 使用数据集中的全套已知 DTI 进行了训练,随后用于预测所有药物的靶蛋白。为了验证这些预测,我们在三个数据库中搜索了支持证据:DrugBank、DrugCentral 和 UniProt。这些数据库包括从 DTI 的规划、实验和发布中获得的信息。表 3 显示了预测结果和验证结果,突出了 TTGCN 强...
书名: Protein-Ligand Interactions 作者: Bohm, H. J. (EDT)/ Schneider, G. (EDT) 副标题: From Molecular Recognition to Drug Design (Methods and Principles in Medicinal Chemistry) 页数: 300 出版社: Wiley-VCH 出版年: 2003-05-06 第1页 Preface ...
Drug Protein Binding refers to the process where drugs attach to plasma proteins like albumin and α 1 -acid glycoprotein, affecting their availability to cross biological barriers such as the placenta. It acts as a reservoir for drugs, influencing their transfer between maternal and fetal compartmen...
An interaction between aspirin and valproate: the relevance of plasma protein displacement drug-drug interactions. An interaction between aspirin and valproate: the relevance of plasma protein displacement drug-drug interactions. Am J Psychiatry 2006; 163(11):1891-6... NB Sandson,C Marcucci,DL Bour...
one may conclude that interactions involving enzyme active sites are not typically considered to be PPIs in the context of drug discovery.34,35,36Instead, binding sites in PPIs usually encompass specific residue combinations, distinct regions, and unique architectural layouts, resulting in cooperative ...
New insights into protein–protein interaction modulators in drug discovery and therapeutic advance Article Open access 06 December 2024 A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery Article Open access 20 April 2024 Accession...
He was diagnosed as having a bipolar I disorder and dementia. He has received aspirin and valproate medications. It was found that aspirin increases the free concentration of valproate.关键词: Drug Interactions Qualitative Displacement Protein measurement Valproate 药物相互作用 ...