磷酸酶抑制剂混合物A (50X)Phosphatase inhibitor cocktail A ,50X10ml10ml168.0 磷酸酶抑制剂混合物B (50X)Phosphatase inhibitor cocktail B ,50X2ml2ml44.0 磷酸酶抑制剂混合物B (50X)Phosphatase inhibitor cocktail B ,50X10ml10ml172.0 磷酸酶抑制剂混合物C (50X)Phosphatase inhibitor cocktail C ,50X2ml2ml14...
In May 2003, the US Food and Drug Administration (FDA) granted accelerated approval for the use of the first-in-class proteasome inhibitor bortezomib as a third-line therapy in multiple myeloma, and the European Union followed suit a year later. Bortezomib has subsequently been approved for mult...
Proteasome inhibitor clioquinol as a candidate drug in prophylaxis and treatment of acute graft-versus- host disease. Med Hypotheses. 2011;76(3):400-402. doi: 10.1016/j.mehy.2010.11.002.Liang Y, Mao X, Liu H. Proteasome inhibitor clioquinol as a candidate drug in prophylaxis and treatment ...
CEP-18770: a novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood 111, 2765–2775 (2008). CAS PubMed Google Scholar Download references Acknowledgements We thank all our colleagues, many of whom we cannot list in this limited ...
DESIGN OF TYROPEPTIN DERIVATIVES Although tyropeptin A is a potent proteasome inhibitor, its inhibitory potency against the chymotrypsin-like activity of 20S proteasome is weaker than that of MG132 (Table 1). To enhance the inhibitory potency of tyropeptin A, we performed a structure-based drug ...
上海玉博生物科技有限公司 主要致力于“Proteasome Inhibitor II (aldehyde) AG总代理 Proteasome Inhibitor II (aldehyde) A ”的生产销售。多年的“Proteasome Inhibitor II (aldehyde) AG总代理 Proteasome Inhibitor II (aldehyde) A ”生产与销售的经验,与各行业新老
Therefore exploring synergistic drug combinations with PIs for effectively combating chemoresistance and limitations of targeted therapy could be a logical therapeutic strategy. As discussed above proteasome inhibitor induced cell cycle arrest is attributed to modulation of one or more pathways. Therefore, ...
Related Compound LibrariesFDA-approved Drug LibraryNatural Product LibraryBioactive Compound Library-IProtease Inhibitor LibraryUbiquitination Compound Library Click to Expand Signaling Pathway Proteasome Signaling Pathway Cell Data Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID ...
Over the past 3 decades, the UPS has been extensively explored as a target for drug discovery,4,5 culminating in the remarkable clinical success of proteasome inhibitor (PI) drugs in the treatment of hematological malignancies including multiple myeloma (MM). Although a great amount of effort ...
The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype. Haematologica 2008; 93: 57–66. 6. Li C, Li R, Grandis JR, Johnson DE. Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes ...