Multiple myeloma (MM) is the most common form of plasma cell malignancy, accounting for about 1.7% of all malignant tumors [1]. Although the use of a variety of treatment options such as high-dose chemotherapy, hematopoietic stem cell transplantation (HSCT), proteasome inhibitors (PIs), immunom...
Many of the actions of melatonin on signal transduction are similar to those of a proteasome inhibitor. While these actions of melatonin could be explained by a direct inhibitory action on the catalytic core particle of the proteasome, this has not been experimentally verified. If our hypothesis ...
Protease vs. Proteinase vs. Proteasome It’s easy to get confused about the many terms that are used when discussing protease. Protease is the general term for enzymes that degrade proteins by hydrolysis of peptide bonds. Researchers realized that there are actually two different types of protease...
chronic ethanol consumption disrupts hepatic biogenesis and inhibits the ubiquitin‒proteasome system by impeding hepatic proteasome activity [55]. In line with previous results, several human and animal studies have shown the involvement of senescence in determining NAFLD [56]. Very recently, restoratio...
Cell‐cyclemegakaryocytemicrotubule inhibitorspolyploidyIn most eukaryotic cells the regular alternation of chromosome reduplication and cell division is controlled ... BVD Loo,Y Hong,V Hancock,... - 《European Journal of Clinical Investigation》 被引量: 77发表: 1993年 Polyploidization and Cancer Limiti...
That’s why in large-cell lymphoma, many groups are pursuing a randomized phase II strategy or other novel statistical approaches to try to take forward a new regimen,” explained Leonard. One such promising regimen is R-CHOP in combination with the proteasome inhibitor bortezomib. This regimen ...
What is a good way to understand the different enzyme inhibitors?? Misfolded proteins are tagged by ubiquitin and then are destroyed by proteasomes. How does ubiquitin know which protein to tag? What is protein A? Describe one method of detecting it. How can kcat be calculated...
Furthermore, novel autophagy inhibitors are in development and promise to provide new therapeutic opportunities for patients with leukemia. This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 251,40...
These newer therapeutics include next-generation proteasome inhibitors (carfilzomib/ixazomib/marizomib) and drugs with alternative mechanisms of action such as monoclonal antibodies Conclusion Published data on the practice of MM treatment in the real world are limited and often difficult to interpret owing...
there is little in the translational/preclinical literature discussing potential mechanisms for synergy between anti-CD38 monoclonal antibodies and proteasome inhibitors. Whether it is simply a matter of two very effective classes of agents being used in combination or whether the...