US20040224900 Mar 2, 2004 Nov 11, 2004 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor peptide analogsUS20040224900 Mar 2, 2004 Nov 11, 2004 Boehringer Ingelheim International Gmbh Protease inhibitors/immunomodulator drugs; internal ribosome entry site (IRES)...
摘要: (57) for the treatment of HIV infection and AIDS and / or protease inhibitors and [summary] The present invention relates to the use of quinoxaline in the three-drug combination of a reverse transcriptase inhibitor.收藏 引用 批量引用 报错 分享 文库来源 求助全文 As AIDS drugs, protease...
The Essential Drug List of the World Health Organization (WHO) includes 13 approved drugs distributed into first-line drugs for initial treatment of HIV and second-line drugs for individuals who have failed first-line treatment.1 In many resource-constrained countries, such as India, current treatm...
Therefore, off-target effects are minimized; and the inhibitors of 3CLpro are most likely less toxic to host cells. Although vaccine development is critically important for COVID-19, effective small molecule antiviral drugs are urgently needed. Recently it was reported that niclosamide, an ant...
Rapid cell-based phenotypic small molecule screens were executed using related common-cold-causing HCoV-OC43 betacoronavirus to identify replication inhibitors from a library of drugs approved by regulatory agencies for other indications. Given the best inhibitors, an expedient checkerboard strategy then ...
In today’s global COVID-19 pandemic crisis, protease studies are more important than ever, since proteases are essential for virus replication of coronaviruses. Existing protease inhibitors are now being added to clinical trials for target SARS-CoV-2 and specific proteases have been under...
In order to inhibit the activation of these NSPs during neutrophil maturation, hence reducing the overall release of proteolytically active NSPs at the site of inflammation and re-establishing a balanced protease-antiprotease environment, CatC inhibitors have been investigated. As a result, several ...
Zika virus protease inhibitors; allosteric inhibitors; Zika virus NS2B-NS3 protease; super-open conformation 1. Introduction The Zika virus (ZIKV) is an emerging, global pathogen declared as a Public Health Emergency of International Concern by the World Health Organization. Approximately 84,000 ...
6a–f; panel-III shows the interaction of the drugs with the lipophilic pocket of the 3CLpro enzymatic site. Fig. 6: Structural analysis and interaction of the potential inhibitors with SARS-CoV-2 3CLpro enzyme. Inhibitors were docked with active site of 3CLpro protein. Panel-I: ligand ...
Recent studies have taken advantage of biochemical properties of specific RAS mutants to develop selective small molecule inhibitors specific for highly oncogenic mutant forms of RAS. In particular, small molecules targeting KRAS G12C have been developed and are undergoing clinical trials14,15,16. ...