今天给大家介绍的是浙江大学侯廷军教授团队发表在Nucleic Acids Research上的一篇文章“PROTAC-DB:an online database of PROTACs”。蛋白水解靶向嵌合体(PROTACs)是一种通过泛素-蛋白酶体系统选择性降解靶蛋白的新型治疗技术,具有传统抑制策略无法比拟的优势。目前PROTAC的设计仍然是一个巨大的挑战,为了对PROTACs进行合理...
今天讲一篇浙江大学侯廷军教授团队发表在Nucleic Acids Research期刊上的关于PROTAC在线数据库的文章,文章提名为PROTAC-DB: an online database of PROTACs。PROTAC这项技术仍日趋成熟,但PROTAC的设计仍然是一个巨大的挑战。为了促进PROTAC的合理设计,文章提出PROTAC-DB,这是一个基于Web的开放访问数据库,它集成了PROT...
Weng G, Shen C, Cao D, et al. PROTAC-DB: an online database of PROTACs[J]. Nucleic Acids Research, 2020. 数据库 http://cadd./protacdb/
5、Weng, G. et al. PROTAC-DB: an online database of PROTACs. Nucleic acids research 49, D1381-D1387, doi:10.1093/nar/gkaa807 (2021). 6、Adhikari, B. et al. PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Naturechemical biology16, 1179-1188, doi:10...
http://cadd.zju.edu.cn/protacdb/ 参考资料: 1#Targeted protein degraders crowd into the clinic(来源:Nature) 2#Gaoqi Weng et al. PROTAC-DB: an online database of PROTACs. Nucleic Acids Research(2020).
[44] Abdel-Magid AF.Inhibitors of the epidermal growth factor receptor (EGFR) may provide effective treatment for lung adenocarcinoma[J]. ACS Med Chem Lett,2015,6(7):732-733. [45] Weng G,Shen C,Cao D,et al. PROTAC-DB:An online database of PROTACs[J]. Nucleic Acids Res,2021,49(...
http://cadd.zju.edu.cn/protacdb/ 参考资料: 1#Targeted protein degraders crowd into the clinic(来源:Nature) 2#Gaoqi Weng et al. PROTAC-DB: an online database of PROTACs. Nucleic Acids Research(2020). 热门疗法/技术/靶点
1)Gaoqi Weng et.al., PROTAC-DB: an online database of PROTACs. Nucleic Acids Res. 2021 Jan8;49(D1):D1381-D1387. doi: 10.1093/nar/gkaa807. 2) Katherine A Donovan et.al., Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10; 183...
Targeted protein degradation by chimeric small molecules, PROTACs and SNIPERs. Front. Chem. 7, 849 (2019). CAS PubMed PubMed Central Google Scholar Weng, G. et al. PROTAC-DB: an online database of PROTACs. Nucleic Acids Res. 49, D1381–D1387 (2021). CAS PubMed Google Scholar ...
5、Weng, G.et al.PROTAC-DB: an online database of PROTACs.Nucleic acids research49, D1381-D1387, doi:10.1093/nar/gkaa807 (2021). 6、Adhikari, B.et al.PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.Nature chemical biology16, 1179-1188, doi:10.1038/s4...