Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasiaUS5981209 * Dec 4, 1997 Nov 9, 1999 Guilford Pharmaceuticals Inc. Detecting cancerous and noncancerous tumors of prostate gland by screening for activity of dipeptide peptidase; incubation of sample tissue or ...
It is the second leading cause of cancer-related deaths in Western males, yet because prostate tumors can take decades to progress to clinically significant disease, they are difficult to diagnose and treat. Latent prostate cancer is common, with many older men showing localized prostate tumors ...
Sarcomatoid Carcinoma of the Prostate Sarcomatoid carcinoma (carcinosarcoma) is a rare type of prostatic cancer with only approximately 100 cases reported in the literature and three large case series consisting of 42, 21, and 12 patients, respectively.8–10 Tumors are most commonly com- posed ...
Gleason grade (Gleason pattern): depending on the degree of differentiation of tumor cells and stromal invasion, tumors are graded from 1 (well-differentiated) to 5 (poorly differentiated) Gleason score (ranges from 2 to 10): the sum of the two most prevalent Gleason grades [32] Grade gr...
Prostate cells are especially prone to mutation and malignant transformation.39-55This process accelerates as men age past 50. Interestingly, cells of other tissues in the anatomical region of the prostate almost never become cancerous. Are there ways to avoid becoming a victim of these grim stati...
The huge communities of microorganisms that symbiotically colonize humans are recognized as significant players in health and disease. The human microbiome
MRI of prostate:Prostate MRI is another way to detect prostate tumors and masses, along with the digital rectal exam (DRE). The doctor can decide how he would like to use this information. It can be used prior to a biopsy to see if any tumor is present. MRI can also be done after ...
(AR) positive, androgen-dependent, secrete PSA, and do not proliferate. Basal cells are androgen receptor negative, androgen-independent, do not secrete PSA, and are capable of regenerating and proliferating. Stem cells may likely be classified more as a basal cell phenotype. Cancerous cells, ...
Chimeric antigen receptor-modified cells for the treatment of solid tumors: First steps in a thousand-mile march Hind Rafei, ... May Daher, in NK Cells in Cancer Immunotherapy: Successes and Challenges, 2023 Prostate cancer Prostate stem-cell antigen (PSCA) and prostate-specific membrane antigen...
In cancer, Notch signaling, initially shown to be oncogenic in human T cell acute lymphoblastic leukemia (T-ALL), and later in other tumors [27–29], was subsequently found to function also as a suppressor of tumor growth, depending on cell lineage or tissue [30–32]. In PC, several ev...