Humphrey and colleagues from the Washington University School of Medicine in Saint Louis, Missouri, which found out that tumor size in prostate cancer specimen predicts recurrence after prostatectomy. Prognost...
Sixteen genes harboured a somatic rearrangement in at least two prostate tumours (Supplementary Table 7), and four contained rearrangements in three out of seven tumours. In addition toTMPRSS2andERG, the latter includedCSMD3andCADM2(cell adhesion molecule 2). These genes were rearranged at a f...
Neoplastic prostate cells interact with surrounding stromal cells, for instance smooth muscle cells, fibroblasts, immune cells, blood and lymph vessels, to create a tumor stroma that facilitates tumor growth and spread1,2. Such interactions also extend beyond the tumor stroma into the tumor-bearing ...
Table 1. Nanomedicines that are clinically approved or in clinical trials. Name of drugMechanism of actionNanocarriersProductStatusRef Doxorubicin Inhibits DNA and RNA synthesis in tumor cells by intercalating between base pairs of DNA strands; generates iron-mediated free radicals, causing oxidative dama...
Table 1. Pearls for managing prostate cancer in the older adults. Take-home pointRationaleClinical application Diagnosing and treating localized prostate cancer in older adults with limited life expectancy is a low-value care practice. Does not reduce mortality, exposed patients to harms from overtreat...
Full size table The receiver operating characteristic curve (ROC) was calculated based on the number of methylated markers and the average methylation of all 32 markers. Figure 1 shows the ROC curves for the nof32, average methylation and PSA for the DRE and the FV data. The Area under the...
Researchers compared MRI-measured tumor size with actualtumor sizeafter prostate removal in 441 men treated for prostate cancer. Improving the ability to better predict ablation margins will allow for more successful treatments for men with prostate cancer and can help reduce the morbidity ofprostate ...
Full size table The current clinical success of radiolabeled PSMA ligands is based on a small motif binding to the catalyticN-acetyl-l-aspartyl-l-glutamate hydrolyzing site in the PSMA molecule. This 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) motif was first described by Koziko...
Full size table Figure 4 Therapy effect on tumor inhibition. The model-predicted effect of (a) single-, (b) dual- and (c) triple-drug therapies. Therapies have been sorted by their tumor inhibition percentage compared to the untreated case, after\(4\)weeks of therapy. Treatments are named...
Full size table Table 5 Cell biological feature related oncogenic functional connectivity map (pathway based) statistics. Full size table Table 6 A summary of inter-hallmark functional connectivity map. Full size table Table 7 A summary of inter-cell biological feature based functional connectivity map...