Humphrey and colleagues from the Washington University School of Medicine in Saint Louis, Missouri, which found out that tumor size in prostate cancer specimen predicts recurrence after prostatectomy. Prognost...
Researchers compared MRI-measured tumor size with actualtumor sizeafter prostate removal in 441 men treated for prostate cancer. Improving the ability to better predict ablation margins will allow for more successful treatments for men with prostate cancer and can help reduce the morbidity ofprostate c...
In cancer immunotherapy, therapeutic agents are used to enhance the host anti-tumour immune response by perturbing the tumor microenvironment24. The idea of modulating the immune response as cancer therapy is a direct consequence of the strong, well recognized interplay between tumors and the immune ...
Full size image To test if such signalling also occurs in patients, we used the prospective study with PCa patients described above. Immunofluorescence signalling levels of PARP1 and its substrate PAR were quantified in cancer areas in corresponding paired slides (Fig.2cand Supplementary Fig.3a)....
T, for tumor, describes the size of the main area of prostate cancer and its spread. N, for nodes, describes whether prostate cancer has spread to any lymph nodes, and how many and in what locations. M, for metastasis, means distant spread of prostate cancer. ...
Men with advanced disease typically undergo androgen deprivation therapy via medical castration that initially reduces tumor burden and symptoms, but castrate-resistant prostate cancer (CRPC) develops resulting in death (Fig. 3). Sign in to download full-size image Fig. 3. Schematic of prostate ...
Computational analysis first predicted a trend of overexpression of mda-9/syntenin mRNA in prostate cancer as compared with normal prostate (Bacolod et al., 2015). Recently, our group evaluated clinical samples (commercial tissue microarray containing 8 adjacent tissue and 64 prostate tumor samples) ...
Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral ... JF Chen,H Hao,J Lichterman,... - 《Cancer》 被引量: 70发表: 2015年 Subclassification of prostate cancer circulating tumor cells by nuclear ...
TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa is unknown. Here we report TRI
Full size image In fact, the regulation of AR expression and function by USP22 in prostate cancer has been reported [37], but whether AR-V7 could be regulated by USP22 is elusive. Our current research focuses on the regulation of AR-V7 protein stability mediated by USP22. Furthermore, CH...