Applications of the pro-state cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for ...
Fig. 1. Prostate cancer cell lines have telomerase activity and short telomeres. (A) Telomere Repeat Amplification Protocol (TRAP) on cell lysates from different prostate cell lines. Normal primary prostate epithelial cells are telomerase negative. The internal amplification standard used for quantifying...
Abstract: Novel human prostate cancer-associated neuroendocrine (NE)-like cell lines are provided that were derived via a process that resembles clinical androgen ablation therapy for advanced prostate cancer. Representative Image: Inventors: Lin, Ming-fong (Omaha, NE) ...
Integrin expression and usage by prostate cancer cell lines on laminin substrata During prostate cancer progression, invasive glandular epithelial cells move out of the ductal-acinar architecture and through the surrounding basement mem... M Edlund,T Miyamoto,RA Sikes,... - 《Cell Growth & Different...
ofinhibinα subunitexpression in high-gradeprostate cancer(Mellor et al., 1998), and evidence that promotermethylationandloss of heterozygosityis associated with the down-regulation of theINHAin prostate cancer cell lines, which is consistent with its tumour suppressive role (Balanathan et al., ...
In lipid metabolism, androgens were able to increase the uptake of fatty acids, cholesterol, and lipoproteins in AR-positive PCa cell lines, which can be blocked by AR antagonists. The expression levels of ACSL3 and ACSL4 are inversely regulated by androgen-AR signaling, and activation of AR ...
Research into the molecular mechanisms underlying the various aspects of prostate cancer (PCa) requires the use of in vivo and in vitro model systems. In the last few years many new cell lines have been established by investigators from primary tissue sources and clonal derivatives of previously ...
prostate cancer cell lines, which represents one of the largest panels of prostate cancer cell lines available to the research community. We had three initial research objectives that we wished to complete. First, we wanted to describe the characteristics of the cell line panel at the molecular ...
We recently tested the possibility of generating metastatic cell lines by culturing the cellular components of cancer-related fluids. Using this approach we have derived primary cultures from pleural effusion and ascitic fluid samples from a warm autopsy and a prostate cancer patient respectively. These...
In addition, a significant subpopulation of VCaP cells appears to have lost the Y chromosome, although this was not reported in the comprehensive SKY analyses of prostate cancer cell lines.63,106 An androgen-independent subline of VCaP has also been generated by subcutaneous propagation of VCaP ...