Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives . Neuroscientist , 2002 , 8 : 12 – 15 .Hayaishi O. and Urade Y. (2002) Prostaglandin D2 in sleep-wake regu- lation: recent progress and perspectives. Neuroscientist 8, 12-15....
4.6.2 Prostaglandin D2 Prostaglandins D2 (PGD2) and metabolites (11 β prostaglandin F2α) are released by lung mast cells and are major product of cyclooxygenase pathway that causes bronchoconstriction and vasodilation in the airways. Increased urinary PGD2 and 11βPGF2 were seen in asthmatic...
[2]. Hayaishi, O. Sleep-wake regulation by prostaglandins D2 and E2. J. Biol. Chem. 263(29), 14593-14596 (1988). [3]. Onoe, H., Ueno, R., Fujita, I., et al. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proc. Natl. Acad. Sci. U.S.A. 85(11), 408...
To examine the function of prostaglandin (PG) D synthase (PGDS) gene, as well as endogenously produced PGD2in sleep regulation in vivo, we generated transgenic (TG) mice that overexpress human PGDS gene to study their sleep behavior. Although no difference was observed in the sleep/wake patte...
Adenosine and sleep-wake regulation. This review addresses three principal questions about adenosine and sleep鈥搘ake regulation: (1) Is adenosine an endogenous sleep factor? (2) Are there spe... R Basheer,RE Strecker,MM Thakkar,... - 《Progress in Neurobiology》 被引量: 1019发表: 2004年 ...
1.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 2.Hayaishi, O.Sleep-wake regulation by prostaglandins D2 and E2J. Biol. Chem.263(29)14593-14596(1988) 3.Onoe, H.,...
1.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 2.Hayaishi, O.Sleep-wake regulation by prostaglandins D2 and E2J. Biol. Chem.263(29)14593-14596(1988) 3.Onoe, H.,...
Rats treated with lithium chloride for 6 weeks have been reported to demonstrate reduced turnover of arachidonic acid (AA) in brain phospholipids, and decreases in mRNA and protein levels, and enzyme activity, of AA-selective cytosolic phospholipase A2(c
Molecular Function: fatty acid binding; prostaglandin-D synthase activity; protein binding; retinoid binding; transporter activity. Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; prostaglandin biosynthetic process; regulation of circadian sleep/wake cycle, sleep; response to ...
(2011). Humoral mechanisms of sleep-wake regulation: historical review of prostaglandin D2 and related substances. Sleep Biol. Rhythms 9, 3-9. doi: 10.1111/j.1479-8425.2010.00448.xHumoral mechanisms of sleep–wake regulation: Historical review of prostaglandin D2 and related substances. Osamu ...