Similar findings were obtained when D2/E2-IsoPs were isolated from hydrolyzed lipid extracts of CCl4-treated rat livers. Unesterified racemic PGD2 was also detected in large quantities (2-4 ng/ml) in urine from these rats. These studies suggest that PGE2 and PGD2 are formed from the ...
26,27 These levels rise further during aspirin-induced reactions, with significant increases demonstrated at the onset of symptoms of clinical reaction in both the plasma26 and the urine.27,28 Additionally, baseline levels of urinary tetranor-PGD-M, one of the major urinary PGD2 metabolites, ...
PGs mainly include prostaglandin D2(PGD2), prostaglandin E2(PGE2), prostaglandin F2α(PGF2α), prostaglandin I2(PGI2), and thromboxane A2(TXA2) (Fig.2). After synthesis, prostaglandins are transported into the extracellular microenvironment through simple diffusion. Subsequently...
(1965)suggested that ethanol administration could be used in acute care of patients ingesting lethal amounts of ethylene glycol antifreeze. The ethanol-treated patients were able to excrete ethylene glycol in the urine instead of converting it to oxalic acid. In a similar manner, methanol poisoning...
Prostaglandin (PG)F2α, E2, D2 and 6-keto-F1α were determined in human cerebrospinal fluid by a mass spectrometric technique. The samples were obtained from 12 patients with suspected intracranial disease. A 64 fold variation in PG levels was observed. The major PG was 6-keto-F1α (0.12...
Prostaglandin (PG) E2, D2, F2α and thromboxane B2 (TxB2) were determined in homogenates of rat brain by gas-chromatography - mass spectrometry. The level ... HBS Ångård - 《Prostaglandins》 被引量: 306发表: 1977年 Antagonism by Fenamates of Prostaglandin F2|[alpha]| and of Slow Re...
REVIEWS Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases Roy Pettipher*, Trevor T. Hansel‡ and Richard Armer* Abstract | Immunological activation of mast cells is an important trigger in the cascade of inflammatory events leading to the ...
with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregati...
A dose- and time-dependent induction of caspase 3 protein procession, and PARP and D4-GDI protein cleavage with activation of caspase 3, but not caspase 1, enzyme activity was detected in HL-60 cells treated with PGD2 or PGJ2. Additionally, DNA ladders induced by PGD2 and PGJ2 were ...
J. Skeletal muscle PGF(2)(alpha) and PGE(2) in response to eccentric resistance exercise: influence of ibuprofen acetaminophen. J. Clin. Endocrinol. Metab. 86, 5067–70 (2001). CAS PubMed Google Scholar Nakagawa, T. et al. A prostaglandin D2 metabolite is elevated in the urine of ...