Using mediator-lipidomics, we found that levels of the urinary prostaglandin D 2 (PGD 2 ) metabolite, tetranor-PGDM, reflected the severity of the allergic symptoms and intestinal mast cell hyperplasia in mice. Repeated oral challenges with ovalbumin promoted allergic symptoms in sensitized mice. ...
The PTGDR2 gene and GPR44 together code for the protein known as prostaglandin D2receptor 2 (DP2 or CRTH2) [91]. It is selectively expressed in Th2 cells, and is therefore a chemoattractant receptor homologous molecule expressed in Th2 cells (CRTH2) [92,93]. PTGDR2, located at q12.2 ...
Prostaglandins have a diverse range of activities and have a well recognized role in pain and inflammation. Prostaglandin D (PGD ) is the 22 main prostanoid produced by mast cells and is the predominant prostaglandin found at sites of allergic inflammation. *Oxagen Limited, 91 Milton Park, ...
Acidic lipids derived from the metabolism of arachidonic acid by the action of cyclo-oxygenase enzymes and downstream synthase enzymes. Prostaglandins have a diverse range of activities and have a well recognized role in pain and inflammation. Prostaglandin D2(PGD2) is the main prostanoid produced...
Prostaglandins (PGs) are a family of oxygenated metabolites of arachidonic acid (AA), and have a diverse range of actions depending on the PG type and cell target. PGs are divided into two groups, conventional PGs such as PGE2, PGF2α, and PGD2 and cyclopentenone PGs such as PGJ2, PGA1...
normal andpathological processes(Cockle et al., 2007). EachMMPpossesses a range ofsubstrate specificities, which results in considerable heterogeneity in their activities. A number of inducible factors including cytokines, hormones (including prostaglandins), andreactive oxygen species(especially nitric ...
Nakagawa T, Takeuchi A, Kakiuchi R, Lee T, Yagi M, Awano H, Iijima K, Takeshima Y, Urade Y, Matsuo M (2013) A prostaglandin D2 metabolite is elevated in the urine of Duchenne muscular dystrophy patients and increases further from 8 years old. Clin Chim Acta 423:10-14....
(D) Primary human statin-treated myotubes regain normal morphology when AL-8810 is added to the medium. (cell populations C12, C13) See also Supplementary Fig. S5. For cell populations used see Supplementary Table S1. [UT, untreated (black); Sim, simvastatin (red); Rosu, rosuvastatin (...
Prostaglandins Other Lipid Mediat 57(2-3): 149-165.O'Sullivan S, Mueller MJ, Dahlen SE, Kumlin M: Analyses of pros- taglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. Prostaglandins Other Lipid Media...
Here, the hypothesis that PGD2-mediated inflammation is involved in the pathology of DMD was examined by measuring tetranor PGDM in urine of DMD patients. We measured tetranor PGDM in the patients' urine samples using LC–MS/MS. One hundred seventeen genetically confirmed DMD patients from 4 to...