The prostaglandins are a family of closely related unsaturated hydroxy fatty acids. They were first found in male accessory glands and their secretions and are now known to occur with widespread distribution in animal and human tissues and body fluids. The term 'Prostaglandin' was coined by von ...
- 《British Journal of Dermatology》 被引量: 27发表: 1975年 Physiological roles and pharmacological actions of prostaglandins in relation to human reproduction (1975). Physiological roles and pharmacological actions of prostaglandins in relation to human reproduction. In Prostaglandins and reproduction, pp...
Release of prostaglandin E and thromboxane from macrophages by stimulation with factor H. Recently novel actions of factor H of complement other than regulation of alternative pathway activation have been described. We examined the influence of ... HP Hartung,U Hadding,D Bitter-Suermann,... - ...
Vane JR, McGiff JC. Possible contributions of endogenous prostaglandins to the control of blood pressure. Circ Res 1975; 36/37 (suppl. 1 ): 68–75. Google Scholar Maher JF, Hirszel P, Lasrich M. Modulation of peritoneal transport rates by prostaglandins. Adv Prostaglandin Thromb Res 1980;...
6) The effects of prostaglandins on the duodenum and the terminal portion of common bile duct are considered to stem from their direct actions on the musculatures of these regions. 7) The findings stress importance of observations with biologically active substances in tissues in the study aimed ...
Potential treatments include: corticosteroids; antioxidants or free radical scavengers; drugs that modify arachidonic acid metabolism, platelet-activating factor antagonists; gangliosides; modulators of monoamine actions; opioid receptor antagonists; thyrotropin-releasing hormone and thyrotropin-releasing hormone ...
Prostanoids, which consist ofprostaglandins(PGs) andthromboxanes(TXs), are biologically synthesized in the body fromarachidonic acidby cyclooxygenase,PGhydroperoxydase, and a family of prostaglandin synthases. They exert a variety of actions as hormones produced locally in various tissues and cells to ...
Table 2.Summary of pharmacological actions ofSpilanthes acmella. 4.1. Local Anaesthetic Activity [17] The local anaesthetic activity ofSpilanthes acmellahas been carried out using two different animal models: (i) intracutaneous wheal in guinea pigs using nupercaine as standard (suitable for determinin...
of 5-HT1B/1Dreceptors (Hoskin et al.2004). In addition, inhibitory actions of 5-HT1B, 5-HT1Dand 5-HT1Freceptors in the trigeminocervical complex of the cat have been documented, and 5-HT1Breceptor-mediated inhibition is the most potent of the three in terms of inhibition of tri...
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective inhibitors but is often preferre...