However, general DNase I sensitivity and DNA methylation patterns were found to be very similar in the mutated cells and in the parental cells. These findings suggest that the promoter and active transcription play a relatively limited role in maintaining transcriptionally potentiated epigenetic states....
Therefore, mutations in both DE1 and DE2 were constructed and shown to be incapable of binding IVa2 protein. They were then placed in the context of the virus to examine the role of the downstream elements in the activation of the MLP. The phenotypes of these mutations, either alone or ...
4d). These results implicate the regulatory role of the PIDSs in transcription and their asymmetric effects on gene expression. The enrichment was much stronger if the control sets were sampled from all genes (Supplementary Fig. 8a). We also performed a similar enrichment analysis (testing ...
Finally, focusing on the dynamics of YY1 uncovered an unexpected role for cohesin in facilitating TF binding. Results Genome-wide identification of transcription-linked chromatin loops Our previous study used Micro-C to reveal that fine-scale 3D genome structure correlates well with transcriptional ...
SQUAMOSA promoter binding protein-like (SPL) family plays vital regulatory roles in plant growth and development. The SPL family in climacteric fruit Carica papaya has not been reported. This study identified 14 papaya SPLs (CpSPL) from papaya genome and analyzed their sequence features, phylogeny,...
TNFalpha induces expression of transcription factors c-fos, Egr-1, and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2. factors Ets-1, Egr-1 and c-fos in different types of vascular lesions, their regulation by TNFα and the role of ERK 1/2 in these signaling...
A role for Kaiso|[ndash]|p120ctn complexes in cancer? Kaiso was first discovered in a complex with the armadillo-domain protein p120ctn and later shown to function as a transcriptional repressor. As p120ctn seems to relieve Kaiso-mediated repression, its altered intracellular localization in ......
synthesis genome-wide, global mRNA levels should correlate better with RNAP occupancy within the TU body than RNAP occupancy at the promoter. Consistent with the rate-limiting role of RNAP escape, mRNA expression levels of the first cistron in the TU did correlate significantly better with the...
In addition, motifs Flw_1 and Flw_6 were present in less than 47% of promoters, so it is possible that their TFs do not act independently at specific distances from the TLS but their role in transcription might be related to the presence of other TFs with which they act in cooperation....
DNA methylation has been suggested to play a role in maintaining the stability of cell differentiation and in regulating gene transcription [17, 18]. It has been recently reported that the selective demethylation of a promoter DNA may be a general mechanism required for the reprogramming of somatic...