Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins contain a conserved motif with the minimal consensus (PxxP) site for Src homology region 3 (SH3)-mediated protein-protein interactions. Nef PxxP motifs show specific binding to biotinylated SH3 domains of Hck and ...
The pp16 protein is a C-terminally located cleavage product of pp24 and contains a proline-rich motif (PPPY) that is conserved among the Gag proteins of a wide variety of retroviruses. By performing a functional analysis of this coding region with deletion mutants, we have shown that the ...
摘要: Presents a study where a proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1. Gas1-dependent signal transduction; In vitro translation and electrophoretic mobility shift assay; Growth arrest analysis of the p53 deletion mutants....
Mutations in the actin binding motif alone did not abolish the activity of CR16 but the mutations in combination with deletion of N-terminal proline rich motif abolished the ability of CR16 to suppress the growth defect. This suggests that the V domain of CR16 has two functionally redundant ...
Critical role of the membrane‐proximal, proline‐rich motif of the interleukin‐2 receptor γc chain in the Jak3‐independent signal transduction 1999. Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor c chain in the Jak3-independent signal transduction...
Homer proteins bind a proline-rich motif that is present in both group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate in a complex that includes Homer. Disruption of the complex, as a consequence of expression of the IEG form of Homer, results in an alteration of mGluR-...
peptide reveals contributions of both WW domains, which also enables tryptophan sandwiching by two proline residues in the ligand. Unexpectedly, a proline-rich motif in the N-terminal region of PRPF40A mediates intramolecular interactions with the WW tandem. Using NMR, ITC, mutational analysis in...
HRGPs are characterized by a repeating motif consisting of a serine residue followed by four hydroxyproline residues. A second group of cell wall proline- rich proteins (PRPs) is expressed in a pattern suggesting a role in plant development (Hong, J. C. et al. (1990) J. Biol. Chem. ...
The current invention discloses a distinct and unique group of Crustacean antimicrobial peptides (AMP) called 'Hyasins'. These novel AMPs are isolated from Crustaceans, more particularly from decapods, and comprise the RPRPF motif in combination with the so-called 'PR-39 motif' RxxPxxP. In a...
Finally, mutational analysis revealed that a PXXP motif at residues 124–127 contributes to the transcriptional activity of TAp63. Altogether, our findings suggest that TAp63 transcriptional activity can be regulated by modification(s) of, or protein interactions with, the p63 proline-rich domain....