Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins contain a conserved motif ...
The pp16 protein is a C-terminally located cleavage product of pp24 and contains a proline-rich motif (PPPY) that is conserved among the Gag proteins of a wide variety of retroviruses. By performing a functional analysis of this coding region with deletion mutants, we have shown that the ...
摘要: Presents a study where a proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1. Gas1-dependent signal transduction; In vitro translation and electrophoretic mobility shift assay; Growth arrest analysis of the p53 deletion mutants....
Mutations in the actin binding motif alone did not abolish the activity of CR16 but the mutations in combination with deletion of N-terminal proline rich motif abolished the ability of CR16 to suppress the growth defect. This suggests that the V domain of CR16 has two functionally redundant ...
Mechanistically, the proline-rich motif-mediated interaction of PRR11 with the p85伪 regulatory subunit of PI3K suppresses p85 homodimerization, thus enhancing insulin-stimulated binding of p110-p85伪 heterodimers to IRS1 and activation of PI3K. PRR11-amplified breast cancer cells rely on PIK3CA and...
Critical role of the membrane‐proximal, proline‐rich motif of the interleukin‐2 receptor γc chain in the Jak3‐independent signal transduction 1999. Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor c chain in the Jak3-independent signal transduction...
Homer proteins bind a proline-rich motif that is present in both group 1 mGluRs and IP3R, and these receptors coimmunoprecipitate in a complex that includes Homer. Disruption of the complex, as a consequence of expression of the IEG form of Homer, results in an alteration of mGluR-...
peptide reveals contributions of both WW domains, which also enables tryptophan sandwiching by two proline residues in the ligand. Unexpectedly, a proline-rich motif in the N-terminal region of PRPF40A mediates intramolecular interactions with the WW tandem. Using NMR, ITC, mutational analysis in...
TDAG 51 protein is rich in PQ ( praline - glutamine ) motif at the C terminal. TDAG51是PQR ( proline-glutamine-rich ) 蛋白,在其C - 端富含PQ即脯氨酸和谷氨酰胺. 互联网 英英释义 Noun 1. an amino acid that is found in many proteins (especially collagen)...
As well as dictating protein structure, these proline-rich regions may contribute to cell adhesion and signalling between cells and the ECM. Collagen chains contain many regions of the repeated motif Gly-Pro-X, where X can represent any amino acid. Many collagens, including type V and the ...