必应词典为您提供proline-rich-domain的释义,网络释义: 脯氨酸富含域;脯氨酸丰富区;富含脯氨酸的结构域;
A mutant p53, lacking a proline-rich domain (p53), that is deficient in controlling both cell death and cell cycle arrest, was employed to determine the biological means by which p53 mediates survival upon DNA damage. While p53and p53cells were equally resistant to many DNA damaging agents,...
Our collective findings provide valuable information on the epitope distribution characteristics of HEV ORF3 and improve our understanding of the influence of the proline-rich domain on the immunoactivity of downstream amino acids in the C-terminal region. 展开 ...
Helton ES, Zhang J, Chen X (2008) The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63. Oncogene 27:2843–2850Helton ES, Zhang J, Chen X. The proline-rich domain in p63 is neces- sary for the transcriptional and apoptosis-...
Here we studied the functional roles of sub-domains within the SLP-76 proline-rich region, specifically the Gads binding domain and the recently defined P1 domain. To gain a further understanding of the functions mediated by this region, we used three complementary approaches as follows: ...
Human phospholipid scramblase 1 (hPLSCR1), a type II integral class membrane protein, is known to mediate bidirectional scrambling of phospholipids in a Ca2+-dependent manner. hPLSCR2, a homolog of hPLSCR1 that lacks N-terminal proline-rich domain (PRD), did not show scramblase activity...
Furthermore, depletion of the proline-rich domain in GPVI (Pro(−)-GPVI) prevented binding of Fyn and Lyn and markedly reduced phosphorylation of FcR γ-chain in transiently transfected COS-7 cells, but did not affect the association of the γ-chain with GPVI. Jurkat cells stably ...
Both z1 pseudorevertants retain the z1 lesion and alter different prolines in a proline-rich region located between the z1 lesion and the self-interaction domain. The pseudorevertants retain the ability to self-interact, but fail to repress white or support transvection at Ultrabithorax. To ...
BackgroundThe interleukin-2 receptor (IL-2R) consists of three subunits, the IL-2Rα, IL-2Rβc, and IL-2Rγc chains. The essential role of the IL-2Rγc cytoplasmic domain, consisting of 86 amino acids, in signal transmission has been well documented. Particularly, the carboxyl ter-...
Moreover, additional experiments indicated that the virus release function of pp16 was abolished by the deletion of only the PPPY motif and could be restored when this motif alone was reinserted into a Gag polyprotein lacking the entire pp16 domain. Single-amino-acid substitutions for any of ...