Lung cancer is the leading cause of cancer-related deaths worldwide, with 50–70% of patients suffering from bone metastasis. Accumulating evidence has demonstrated that miRNAs are involved in cell proliferation, migration, and invasion in malignancy, su
It is necessary to create novel, efficacious and harmless therapeutic strategy for lung cancer treatment. The application of nanoemulsion to specifically suppress cancer progression in the tumor microenvironment would be an effective therapy. Neobavaisoflavone (Neo) is an isoflavone isolated from Psoralea...
Interstitial lung disease in lung cancer: separating disease progression from treatment effects. Drug Saf 2005;28:103-113Danson S, Blackhall F, Hulse P, Ranson M. Interstitial lung disease in lung cancer: separating disease progression from treatment effects. Drug Saf 2005;28:103-113....
step model. in subsequent discussions with several panel members, they suggested that lung cancer progression may be a 2-step or 3-step process in different patients. there was clear consensus that treatment is delayed by approximately 1 tvdt in patients who undergo a period of observation, or...
(CD86+ CD11b+ ) macrophages in THP-1-derived Mφs after overexpression of SPLUNC1 with or without treatment with JAK/STATs pathway inhibitors (AG490, Ruxolitinib) was detected by flow cytometry.DAfter stimulation with LPS/IFN-γ for 0, 15, 30, 60, 90, 120 min, the protein ...
Studies in this transgenic strain demonstrated an increase in CYP1A1 expression in both liver and lung, following treatment of PAHs, such as 5-methylchrysene and 7,12-DMBA. Hence, the carcinogenic potential of CYP1A1 in the activation of PAHs has been well documented both in vitro and in ...
Figure 4. Association of Circulating Tumor (ct)DNA Persistence With Survival View LargeDownload A, Progression-free survival (PFS) in patients with EGFR-mutant lung cancer stratified by clearance of ctDNA after 6 weeks of treatment with osimertinib and bevacizumab. B, Overall survival (OS) in pa...
1 Across the globe, 10 million people died from cancer in 2022. Timely screenings are known to increase earlier detection, with a lower stage at diagnosis typically leading to a more favorable treatment response. A study published in JAMA Oncology revealed that the pandemic resulted in a ...
fostering an immunosuppressive environment that inhibits the immune response against the tumor7. This dynamic within the TME has profound implications for therapeutic strategies, especially immunotherapies, emphasizing the importance of understanding these interactions to enhance the efficacy of cancer treatment...
Significantly high-expressed circFLNA has been found in various cancer cell lines, but not in lung cancer. Therefore, this study aimed to explore the role of circFLNA in the progression of lung cancer. The target gene of circFLNA was determined by bioinf