These results provide new insight on the significance and mechanism of neural cell death in mammalian brain development.Chia-Yi Kuan and Kevin A. Roth and Richard A. Flavell and Pasko RakicTrends in NeurosciencesKuan CY, Roth KA, Flavell RA, Rakic P. 2000. Mechanisms of pro- grammed cell ...
Programmed cell death p53 Mitochondria Apoptosis Necroptosis 1. Introduction For many years, the concept of naturally occurring cell death has been divided into necrosis and apoptosis. In the 1970s, development of electron microscopy enabled distinguishment for these different modes of cell deaths by a...
Bcl-2 and the regulation of programmed cell death 喜欢 0 阅读量: 180 作者: John C. Reed 摘要: Programmed cell death (PCD) is used to describe a mechanism of cellular demise that is believed to play an important role in a wide variety of physiological situations. The bcl-2 gene has...
The concept of cell death has been expanded beyond apoptosis and necrosis to additional forms, including necroptosis, pyroptosis, autophagy, and ferroptosis. These cell death modalities play a critical role in all aspects of life, which are noteworthy fo
[99]. Zhang et al. observed that PARP1 amplification was linked to increased immune cell infiltration along with the expression of immune checkpoint genes, indicating that patients with elevated PARP1 expression may benefit from ICI treatment [100]. However, the mechanism of PARP and ICI remains...
Under the name of programmed cell death (PCD) are included diverse molecular mechanisms of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is...
Each cell has a distinct history and metabolism, so that each cell responds differently in timing and response to the same stimulus. We need to know much more about what determines the threshold at which the cell death mechanism is activated. Autophagy appears to be a response to penury and ...
Despite the introduction of therapeutic hypothermia, neonatal hypoxic ischemic (HI) brain injury remains a common cause of developmental disability. Development of rational adjuvant therapies to hypothermia requires understanding of the pathways of cell death and survival modulated by HI. The conceptualizatio...
Once activated, the RIP kinases phosphorylate an effector molecule, such as themixed lineage kinasedomain-like (MLKL) molecule, which disrupts the cell membrane.9This mechanism of programmed membrane disruption is analogous to the execution of pyroptosis by GSDMD. As a lytic form of cell death, ...
Is autophagy a cell death mechanism? Here, we carefully review the data that support autophagy as a bona fide mechanism of cell destruction. For many years, necrosis was regarded as an unregulated mode of cell death that was caused by overwhelming trauma. Here, we examine a regulated form of...