ma derived cell line (CO). Sequence analysis revealed the deletion of an adenine base at position 1907 in the open reading frame in one p85α allele, thereby deleting most of the c-terminal SH2 domain. PI3K is constitutively active in CO cells [17]. This mutant does not confer to factor...
2002. Programmed cell death induced by (b-galactosyl)3 Yariv reagent in Nicotiana tabacum BY-2 suspension-cultured cells. Physiologia Plantarum 116, 548-553.Chaves I, Regalado AP, Chen M, Ricardo CP, Showalter AM (2002) Programmed cell death induced by (b-galactosyl...
The p53 tumor suppressor continues to hold distinction as the most frequently mutated gene in human cancer. The ability of p53 to induce programmed cell death, or apoptosis, of cells exposed to environmental or oncogenic stress constitutes a major pathwa
BACKGROUND:Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PDCD-1 that mediate...
Although the concept of programmed cell death (PCD) in bacteria has been met with scepticism, a growing body of evidence suggests that it can no longer be ignored. Several recent studies indicate that the phenotypic manifestations of apoptosis, which are processes that are associated with ordered ...
programmed cell death-1 inhibition in lymphoma 热度: Nuclear dynamics and programmed cell death in Arabidopsis root hairs 热度: FunctionalMappingforGenetic ControlofProgrammedCellDeath YuehuaCuiandRonglingWu DepartmentofStatistics,UniversityofFlorida,Gainesville,FL32611 ...
Programmed cell death (PCD) has emerged as a critical regulatory mechanism in the initiation and progression of various pathological conditions. PCD in microglia, including necroptosis, pyroptosis, apoptosis, ferroptosis, and autophagy, occurs in a variety of central nervous system (CNS) diseases. Dysr...
Programmed cell death 1 has been reported as a potential target in several malignancies, and targeting agents are being developed, some already approved by FDA, such as: pembrolizumab, Atezolizumab, Nivolumab. Pembrolizumab that have been approved for the treatment of metastatic non-small cell lung ...
Cell death. Cell. 2024;187(2):235–56. Article CAS PubMed Google Scholar Yuan J, Ofengeim D. A guide to cell death pathways. Nat Rev Mol Cell Biol. 2024;25(5):379–95. Article CAS PubMed Google Scholar Kulkarni M, Hardwick JM. Programmed cell death in unicellular versus ...
Anti-programmed cell death-1 therapy in nonmelanoma skin cancer. Br J Dermatol. 2016;176(2):498-502.Anti-PD-1 therapy in nonmelanoma skin cancer. Winkler JK,Schneiderbauer R,Bender C,et al. Br J Dermatol . 2016Winkler JK, Schneiderbauer R, Bender C, Sedlaczek O, Frohling S, Penzel...