Carcinoma of the breast, lung or prostate cause the majority of all bone metastases. Prolonged survival is common in patients with breast or prostate tumours. Different types of treatment may significantly increase the quality of life. Single-dose or fractionated radiation therapy may be effective, ...
Unfortunately, some patients suffer from advanced PCa within two years due to the development of bone metastases13,14. Approximately 10% of newly diagnosed PCa patients present with bone metastasis, increasing to 80% at advanced stages of the disease15,16. Butler SS et al. reported that the in...
Approximately 70% of patients with advanced breast cancer develop bone metastases, accompanied by complications, such as bone pain, fracture, and hypercalcemia. However, our understanding of the molecular mechanisms that govern this process remains fragm
There is also ongoing concern that the IPSS accords more prognostic weight to an increase in bone marrow blasts compared with poor-risk karyotypes, for example, 2 points are assigned for bone marrow (BM) blasts in the 21% to 30% range, and 1.5 points for the 11% to 20% range, whereas...
(death) rates mainly due tosepsisfrom the chemotherapy. External beam radiation therapy is mainly used in other countries; it is infrequently used in the United States as a primary treatment. Its use to reduce pain from metastases of bladder cancer, especially to the bones, is still of value...
Another category of medications calledbisphosphonateswas recently approved for postmenopausal people who have early-stage breast cancer. Thebisphosphate medication Zometa (zoledronic acid)appears to reduce the risk of developing bone metastases.10(The bones are the most common site of metastases with breast...
11 To our knowledge, all studies evaluating luminal/basal subtypes within prostate cancer have been limited to primary prostate cancer tissue, in part due to the difficulties in obtaining biopsies from metastases, which are often confined to bone. Metastatic castration-resistant prostate cancer (mCRPC...
This study identified the age-related incidence and risk factors of brain metastases in HCC patients. These results may contribute to the consideration of brain screening among patients with initial metastatic HCC with lung or bone metastases, and influence the counseling of this patient population reg...
As used herein, the phrase “bone-related disorder” refers to a disorder wherein bone formation, deposition, or resorption is abnormal. Bone-related disorders include, but are not limited to, osteoporosis, hypercalcemia of malignancy, osteopenia due to bone metastases, periodontal disease, hyperparat...
the technique improved diagnosis and clinical decisions about treatment. In 88 percent of subjects, 18F-FES PET was found to improve diagnostic information, and in 48 percent, it prompted a change in treatment. This molecular imaging technique was especially helpful for detecting bone metastases. ...