Process for producing human monoclonal antibodiesdoi:EP0431125 A1The process of the invention comprises the following steps: (a) isolation and preparation of cells exhibiting antigens, TH and B cell precursors from tumour-infiltrated people, those infected with procaryotic or eucaryotic exciters, ...
The development of biotherapeutics like antibodies comes with many challenges. Learn more about monoclonal antibody process development..
Monoclonal antibodies constitute a robust class of therapeutic proteins. Their stability, resistance to stress conditions and high solubility have allowed the successful development and commercialization of over 40 antibody-based drugs. Although mAbs enjoy a relatively high probability of success compared wit...
, including monoclonal antibodies Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional ...
Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL...
FRAGMENTS OF MONOCLONAL ANTIBODIES SPECIFIC TO THE PRESENCE OF ACTIVE LEUKOCYTES - THEIR PROCESS FOR OBTAINING AND THEIR APPLICATION IN THE CASE OF A GRAFT... Fragments of antibodies capable of attaching themselves to an antigenic site of a receptor present on the activated leucocytes. The invention...
(CROs) have routinely analyzed HCPs by LC–MS in various protein biopharmaceuticals, including monoclonal antibodies (mAbs), vaccines, and other biologics. Several analysis workflows have proven successful with instruments from different vendors, different database search software, and different ...
The successful use of monoclonal antibodies (mAb)s in the treatment of cancer and autoimmune diseases has made them one of the fastest growing classes of new drug products approvals [1]. Hundreds of new biopharmaceutical drug approvals and thousands more currently in development fuel expectations ...
However, in cell culture-based process studies, monoclonal antibodies are generally the target for protein production, and the quality attributes are usually similar. Therefore, application of the QbD concept to rFVIII production should be interesting because the quality attributes may make unique ...
This invention belongs to the field of biotechnology; namely, it describes a process to generate monoclonal antibodies using recombinant chimeric virus-like particles with inserted foreign protein fragments as immunogens. This process can be applied in hybridoma technology to generate new monoclonal antibo...