A period of about three to four hours (one half-time for renal elimination, ordinarily) should elapse after the last intravenous dose before administering the first dose of Procainamide Hydrochloride tablets or capsules. DILUTIONS AND RATES FOR INTRAVENOUS INFUSIONS* Procainamide Hydrochloride Injection...
Nexus Pharmaceuticals disclosed on Thursday the availability of Procainamide HCL Injection, USP in a multi dose vial containing 1,000 mg per 2 mL (500 mg/mL) or as a multi dose vial containing 1,000 mg per 10 ml (100 mg/ml) in the US with immediate effect. Nexus Pharmaceuticals reports...
Max dose is 17mg/kg. Use is discontinued when dysrhythmia is suppressed, or if hypotension ensues, QRS complex widens by 50% or more, or maximum dose is achieved. Side effects:Adverse effects include rash, myalgia, hypersensitivity reactions (fever, agranulocytosis), Drug-Induced Lupus ...
DOSE INTERVALS FOR PROCAINAMIDEdoi:10.1016/S0140-6736(75)92647-1MarcusMReidenbergSDOSLancet
Procainamide was administered to the procainamide group within 1 hr of the patient's arrival in the intensive care unit and consisted of an intravenous loading dose (12 mg/kg) followed by a maintenance dose (2 mg/min) of procainamide. The control group received a similar volume of placebo. ...
With the 500 mg dose, there was a small difference (p < 0.05) in the directional change of cardiac index which was dependent on the control values: the variable rose slightly in patients with normal indexes whereas it declined slightly in those with low values. Significant Q-T prolongation ...
3-chloroprocainamide (3-CPA), an analog of metoclopramide (MCA), dose-dependently inhibited tumor growth in scid mice xenografted with a human brain astroc... J Hua,RW Pero - 《Acta Radiologica Therapy Physics Biology》 被引量: 13发表: 1997年 Synthesis, characterization, and assessment of ...
Clinically relevant doses of PA produced a dosedependent decrease in the amplitude of spontaneous miniature endplate potentials (MEPPs) and a marked increase in the half-decay time without altering MEPP frequency or resting membrane potential. The amplitude of impulse-evoked end-plate potentials was ...
From the standpoint of managing individual patients with , the pharmacokinetics of this drug continue to provide the scientific basis for designing dose regimens that will have maximal antiarrhythmic efficacy and minimal toxicity. This review summarizes the salient features of pharmacokinetics and outlines ...
Overall the mean steady state plasma concentration of PA (Cpss) expressed as a fraction of dose did not depend on dose or on acetylator status, but the HS group had significantly higher Cpss per gram dose (6.3 mug/ml) than LS (2.7 mug/ml) or the HF (2.3 mug/ml) groups. Clearance ...