(1980) Large dose procainamide therapy for ventricular tachyarrhythmia. American Journal of Cardiology 46: pp. 453-462Greenspan, A.M. , Horowitz, L.N. , Spielman, S.R. & Josephson, M.E. ( 1980 ) Large dose procainamide therapy for ventricular tachycardia . American Journal of Cardiology ,...
Procainamide is intended for treating paroxysmal atrial tachycardia, atrial fibrillation, premature ventricular contraction, and ventricular tachycardia. For quickly reaching therapeutic concentrations, parenternal introduction of procainamide is preferred over cynidine. Definition ChEBI: 4-Aminobenzamide substituted...
Procainamide hydrochloride injection is indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgement of the physician, are life-threatening. Because of the proarrhythmic effects of procainamide, its use with lesser arrhythmias is gener...
This dose was continued for three years, and was subsequently reduced to 8.0 gm daily. Any further reduction precipitated recurrent arrhythmia. Up to the present time, this patient has taken the large doses of the drug for seven years, without evidence of lupus erythematosus or other toxic ...
The mean dose of procainamide was 1194 卤 495 mg/die. Procainamide therapy significantly decreased ICD interventions (DC shock: 102 vs 132; anti-tachycardia pacing: 418 vs 603; 12 patients manifested DC shock after the beginning of treatment vs 25 patients before treatment). Procainamide also ...
Introduction: The safety and efficacy of IV procainamide is well established in adults, however data in pediatrics is more limited.Methods: Prospective cohort study including children <18 yrs old who received IV procainamide for supraventricular tachycardia (SVT) or junctional ectopic tachycardia (JET)...
We examined PA elimination kinetics following a single intravenous dose (range 4-30 mg/kg) in 5 patients (pts), ages 6-16 yrs, (ventricular tachycardia 3 pts, atrial flutter 2 pts). Serial blood samples were analysed for PA and N-acetyl procainamide (NAPA) by a gas chromatographic assay...
As single agents, intravenous procainamide and oral amiodarone produced equivalent increases in QRS duration, rate-corrected QT interval, right ventricular effective refractory period, and cycle length of induced ventricular tachycardia. After the addition of intravenous procainamide to amiodarone the QRS ...
Ventricular tachycardia persisted with poor peripheral pulses, a severely dampened arterial waveform, and a MAP of 30 to 45 mm Hg. Two milligrams/kg IV procainamide was administered over 3 minutes, 3 separate times, at 5-minute intervals. Immediately following the third dose sinus rhythm was ...
Antiarrhythmic properties of N-acetylprocainamide (NAPA), an active metabolite of procainamide, were studied in 12 patients with coronary artery disease who presented with cardiac arrest or documented sustained ventricular tachycardia (VT). Programmed electrical stimulation (PES) studies were performed in ...