Route of AdministrationINTRAMUSCULAR, INTRAVENOUS Active Ingredient/Active Moiety Ingredient NameBasis of StrengthStrength PROCAINAMIDE HYDROCHLORIDE(UNII: SI4064O0LX) (PROCAINAMIDE - UNII:L39WTC366D)PROCAINAMID
Grave hypotension and cardiac abnormalities are, however, major side-effects when procainamide is given too rapidly intravenously, and hypersensitivity reactions are an additional danger of long-term use. It is readily absorbed via the oral route, and acetylated in the liver to N-acetylprocainamide ...
Acute cardiovascular reactions to procainamide administration include hypotension, A-V block, intraventricular block, ventricular tachyarrhythmias, and complete heart block. The drug dosage must be reduced or even stopped if severe depression of conduction (severe prolongation of the QRS interval) or repol...
N-acetylprocainamide absorption following oral administration is more than 80% complete. 59 to 89% of N-acetylprocainamide is excreted unchanged in the urine in subjects with normal renal function. Deacetylation of N-acetylprocainamide to procainamide is a minor route of N-acetylprocainamide ...
Percutaneous absorption of antiarrhythmic agents may provide a potentially useful and reliable route for continuous, slow administration of these drugs.N.UniversityBaileyUniversityDavidUniversityInformahealthcareCutaneous & Ocular Toxicology