Objective: To examine the proapoptotic properties of Oroxylum indicum methanol extract on cervical cancer cells. Methods: Methylene blue assay was used to determine the IC50 value of the extract. Western blotting assays were done to analyze the expression of HPV oncoproteins (HPV18 E6 and E7) ...
Tumor necrosis factor-related apoptosis-induc- ing ligand (TRAIL) protein-induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic clus- ter sorting protein-2 (PACS-2). J Biol Chem. 2012;287(29):24427-37....
Weber A, Kirejczyk Z, Besch R, Potthoff S, Leverkus M, Hacker G (2010) Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells. Cell Death Differ 17(6):942–951. ...
Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells. Cell Death Differ. 2010; 17:942-951. [PubMed: 20019748]
Mata M, Pallardo F, Morcillo EJ, Cortijo J. Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H(2)O(2) via mechanisms involving AP-1 activation . Free radical research . 2012; 46 ( 5 ):690–9. doi: 10.3109/10715762.2012.669040 ....
The present invention concerns an antibody, or functional fragment thereof, which binds specifically to the O-acetylated-GD2 ganglioside, said antibody comprising a) a light chain comprising three light chain complementary regions (CDRs) having the following amino acid sequences: the light chain CDR...
2007. Death- receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat. Med. 13: 1070 -1077.Wagner, K.W.; Punnoose, E.A.; Januario, T.; Lawrence, D.A.; Pitti, R.M.; Lancaster, K.; Lee, D.; von Goetz, M.; Yee, S.F.; Totpal, ...
Antibody against GD2-O-acetylated ganglioside having pro-apoptotic activityThe present invention relates to an antibody or a functional fragment thereof that specifically binds to O-acetylated-GD2 ganglioside, wherein the antibody comprises: a) an amino acid sequence selected from the following amino ...
Antibody which binds to the O-acetylated-GD2 ganglioside, includes: a) a light chain including three light chain complementary regions (CDRs) having the following amino acid sequences: CDR1: QSLLKNNGNTFL (SEQ id no 1), CDR2: KVS, CDR3: SQSTHIPYT (SEQ id no 2); and a light chain...
Proapoptotic Effects of S-Nitrosothiols O-Chloro and M-Chloro S-Nitroso-Aryl-Amides in Human Breast Cancer Cell Linesdoi:10.1016/B978-0-12-816545-4.00029-3Arnold SternAdriana K.C.A. ReisRafaella C. da SilvaHugo P. Monteiro