Mechanistically, we revealed that inhibition of pro-ferroptotic signaling facilitates the nuclear-cytoplasmic shuttling of proliferator-activated receptor-纬 and, thereby impeding nuclear receptor coactivator 4-ferrtin complex-centric ferritinophagy. Finally, the activated pro-ferroptotic signaling correlates...
Mechanistically, activation of the JAK/STAT3 pathway by JAK1 or JAK2 overexpression attenuated VAMP8 silencing-mediated anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on CRC cells. In conclusion, VAMP8 knockdown affects the proliferation, apoptosis, autophagy, and ...
Late Breaking Abstract - Transcriptomic profiling identifies pro-fibrotic macrophages under ferroptotic stress in silicosisdoi:10.1183/13993003.congress-2023.PA2233BiomarkersBronchoalveolar lavageOccupationBackground:Silicosis is an incurable fibrotic lung disease caused by inhalation of respirable crystalline ...
immunogenic cell deathimmunotherapyTumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFN纬 produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family ...
muscaria was 168.96 (after 24 h) and 43.85 (after 72 h) 渭g/mL, inducing mainly a proapoptotic effect on choriocarcinoma cells. The extract also demonstrated an antiferroptotic effect. Both the proapoptotic and antiferroptotic effects were achieved regardless of the inductio...
Our previous work has documented the presence of characteristic pro-ferroptotic signals – peroxidized derivatives of PUFA-PE – in several types of cancer cells such as human fibrosarcoma HT-1080, human SH-SY5Y neuroblastoma, MDA-MB and BT-20 breast cancer cells [20,30,31]. We also perform...
6 cells using two independent sgRNAs and confirmed that loss of Prmt1 blocked erastin-induced cell death as indicated by cell viability, which could be reversed by the addition of ferroptosis inhibitor liproxstatin-1, supporting the pro-ferroptotic effect of PRMT1 (Figures 1D and S1A–S1C)....