pro-inflammatory molecules 促炎性分子
Interestingly, p38MAPK which induced pro-inflammatory molecules in ALS pre-treated MΦs is also one of the key molecules that participate in phagosomal maturation40,41and attenuateLeishmaniagrowth within the host MΦs40. In order to ascertain the role of p38 MAPK in phago-lysosome fusion in our...
We evaluated the role of NLR family pyrin domain containing 3 (NLRP3) inflammasome in sterile corneal inflammation caused by lipopolysaccharide (LPS) or alkali burns in C57BL6 mice or NLRP3 KO (Nlrp3−/−) mice. Various molecules related to the NLRP3
Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells 2008. Suppression of pro-inflammatory adhesion molecules by PPAR-δ in human vascular endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28... Y Fan,Y Wang,Z Tang,... - 《...
qPCR analysis revealed an LPS-induced increase in the local expression of TNF (Figure 4a) and IL-6 (Figure 4b), two well-validated inflammatory molecules. Both TNF and IL-6 were induced to a significantly lower degree in the ileum of MMP7−/− mice compared with MMP7+/+ mice, ...
Pro-inflammatory molecules including IL-6, IL-1β, and TNF-α have been identified as pro-coagulant mediators in numerous investigations (Camprubí-Rimblas et al., 2020; Du et al., 2022). Excess cytokines from endothelial cells and activated monocytes cause a TF release, which starts the ...
Although the main modulator of this molecules is the iron availability, ferritin synthesis may also be regulated by different inflammatory cytokines17, thus suggesting a possible role in inflammation18,19. On these bases, in this work, we aimed at assessing the presence of FeH and FeL in bone ...
Furthermore, FAK/Pyk2 activity was not limited to CAM expression but was also required for expression of various pro-inflammatory molecules including MCP-1 and IP-10. Both TNF-α and IL-1β signaling requires FAK/Pyk2 activity to activate ERK and JNK MAPKs leading to inflammatory gene ...
Of note, PAPCs have been studied in the past by other research groups, but most research in this area has focused on their ability to act as anti-inflammatory molecules. The current discovery that PAPCs act to promote immunity, rather than inhibit immunity, distinguishes the currently described...
In conclusion, PPARα-stimulation prevents overexpression of pro-inflammatory molecules and preserves viability in an experimental model of acute MI. 展开 关键词: PPAR iNOS fibrates myocardial infarction interleukins cell adhesion molecules matrix metalloproteinases NF-kappa B I kappa B DOI: 10.1139/...