The experiments confirmed the presence of the ACE2 receptor in human skeletal muscle cells. It has also been documented that the SARS-CoV-2 virus spike protein influences the activation of selected pro-inflammatory proteins that promote cytokine storm and oxidative stress in muscle cells. The use ...
Pro-inflammatory S100 proteins are associated with glo- merulonephritis and anti-dsDNA antibodies in systemic lupus erythemato- sus. Lupus 2017;(26):139-149. [2] Tantivitayakul P, et al. Elevated expressions of myeloid-related proteins-8 and -14 are danger biomarkers for lupus nephritis. ...
and granulocytes. IL-6 stimulates several types of leukocytes and the production of acute phase proteins in the liver. It is particularly important in inducing B-cells to differentiate into antibody-forming cells (plasma cells). Binding of IL-6 to its receptor init...
For the peroxynitrite-modified proteins, we found a strongly enhanced activation of TLR4 and the pro-inflammatory transcription factor NF-κB in stable reporter cell lines as well as increased mRNA expression and secretion of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-8 in human mono...
[9]. While RA is however a systemic inflammatory auto-immune disease, OA is characterized by local low-grade inflammation with moderately elevated pro-inflammatory proteins in the plasma and synovial fluid [10]. Interestingly, the density of CGRP-positive nerve fibers is reportedly higher in the ...
proteins were separated by SDS PAGE and immunoblotted with specific antiserum. These blots revealed a significant (p < 0.05) decrease in the expression of GSTA1/2, and GSTM2 (lower band) (Fig.1e–g). However, the expression of GST subunits such as GSTP1, GSTK1, GSTO2, GSTT1 ...
Changes to immunomodulatory proteins were minimal, with IL-12(p70), IL-13 and VEGF significantly lower in mild endometriotic women compared to non-endometriotic women (−39%, −54% and −76% respectively). Verification using C-reactive protein as a non-specific marker of inflammation ...
Gabay C, Singwe M, Genin B, et al (1996) Circulating levels of IL-11 and leukaemia inhibitory factor (LIF) do not significantly participate in the production of acute-phase proteins by the liver. Clin Exp Immunol 105:260–265 PubMedCASGoogle Scholar ...
ApoE synthesized in hepatocytes is secreted into the plasma circulation, where it serves as the ligand that mediates lipoprotein binding to low-density lipoprotein (LDL) receptor family proteins and cell surface heparan sulfate proteoglycans for the clearance of triglyceride-rich lipoproteins from the ...
protease, proteins involved in iron uptake and Tfp assembly [27]. The coordination of capsule formation and pili gene expression maximizes the virulence and transmission of Nm. The effects of Nm on the host and the inflammatory response caused by Nm infection have been investigated at ...