Despite broad scientific interest in harnessing the power of Earth’s microbiomes, knowledge gaps hinder their efficient use for addressing urgent societal and environmental challenges. We argue that structuring
The introduction of the “adaptive genome” concept allows us to extend the notion of a single host to that of a “meta-host”, thereby gaining a comprehensive understanding of disease heterogeneity or the success rate of organ transplantation resulting from host-microbiome interactions. To address...
of their bulk elements due to distinct interactions with visible light by the surface atoms of the nanomaterial. Extending this observation to more recent applications, just changing the size of semiconducting quantum dots results in clearly noticeable changes in their fluorescence color or emission wave...
Against this backdrop, the proximity ligation assay (Fredriksson et al., 2002; Soderberg et al., 2006), a highly specific technology previously employed for examining the subcellular localization of protein-protein interactions, has been combined with Cas9/sgRNA for mitochondrial DNA in situ labeling...
To systematically characterize the function and interactions of their binding sites, we designed three main MPRA libraries (Figure 1D; Table S1): Library A investigated the function of binding sites of individual TFs in the context of random DNA. It contained candidate enhancer sequences with one ...
For starters,eat something (sensible).Studies have shown that a dose of glucose restores willpower and the ability to make better, well-thought-out decisions. In other words, a healthy snack with a bit of protein can reset the brain, and give you the boost of energy you need to stay ca...
Extension of AlphaFold to support prediction of multimeric protein structures from sequences. Aronson, A., Hochner, T., Cohen, T. & Schneidman-Duhovny, D. Structure modeling and specificity of peptide–MHC class I interactions using geometric deep learning. Preprint at bioRxiv https://doi.org/...
Communication between these lymphocytes occurs via two major modalities: secretion of soluble proteins such as cytokines and chemokines and surface ligand-receptor interactions. These signals alter the functional state of the receiving (and sometimes the sending) cell. Collectively, these cell populations,...