Principles of protein-protein interactions: what are the preferred ways for proteins to interact? Chem Rev. 2008;108(4):1225-44.Keskin O, Gursoy A, Ma B, Nussinov R. Principles of protein-protein interactions:
PROTEIN-protein interactionsINTERMOLECULAR interactionsMOLECULAR associationADAPTOR proteinsCELLULAR signal transductionIn contrast to fossorial and above-ground organisms, subterranean species have adapted to the extreme stresses of living underground. We analyzed the predicted protein-protein interactions (PPIs) ...
Direct reading of a DNA sequence generally occurs via the hydrogen-bonding edges of the bases for small molecules; therefore features are required of a protein that enable the bases to be accessed through either major or minor grooves. The B-DNA major groove is the richer of the two grooves...
Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topic. H
interactions (↓α-helice, β-sheet) ↑ rotational freedom ↑ Sconformational (spontaneous) (effect more pronounced for “soft proteins” on hydrophobic surfaces) 16 3 - Which aspects of protein adsorption may have interest to study? Adsorption mechanism � � � 1- Transport toward the su...
Abstract Detecting protein-protein interactions (PPIs) provides fundamental information for understanding biochemical processes such as the transduction of signals from one cellular location to another; however, traditional biochemical techniques cannot provide sufficient spatio-temporal information to elucidate the...
Metabolite-protein interactions typically result in local or in global alterations of protein structures (Boehr et al., 2009,Nussinov and Tsai, 2013). We reasoned that detecting ligand-induced structural alterations on a proteome-wide scale could provide a universal readout of protein-small molecule...
drug and protein receptor [21]. These descrip- tors can be used independently or combined i.e. only those of the protein receptor or/and of the drug (peptide or small chemical compound). This approach refers to chemometrics applied to proteins. Interactions between amino-acids residues at ...
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resulting from mutations and epigenetic alterations acquired during cancer evolution result in non-physiological patterns of genome expression, degrading the functional proteome.75,76,77,78,79Normal developmental programs are temporally regulated by a network of interactions. The cells cascade down Waddington...