Using pmel-1 T-cell receptor transgenic mice, we found that pmel CD8+ T cells activated in the presence of IL-12 (pmelIL-12) showed much greater expansion in an irradiated (6 Gy) host compared to cells activated without IL-12 (pmelsham). This expansion was dependent on host IL-7, ...
CD8 T cells primed by transplantation recognize allogeneic class I MHC molecules expressed on graft vascular endothelium and contribute to allograft injury. We previously showed that immune cell-derived complement activation fragments are integral to T cell activation/expansion. Herein we tested the impact...
While it is well known that CD4+ T cells and B cells collaborate for antibody production, our group previously reported that CD8+ T cells down-regulate alloantibody responses following transplantation. However, the exact mechanism involved in CD8+ T cell–mediated down-regulation of alloantibody re...
To prevent bystander destruction of healthy host tissues, cytotoxic CD8(+) T lymphocytes are fitted with specific receptors that direct their destructive forces specifically against chosen targets. We show here, however, that anti-H-Y monospecific, H-2(b-restricted MataHari CD8(+) T cells reject...
Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with nave CD8+ T cells in the mouse Large number of T cells traffic through the liver. In order to examine the effects of such traffic on the phenotype of hepatocytes, we vaccinated mice using DNA vaccines ...
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection J. Virol., 68 (1994), pp. 8056-8063 Google Scholar 14 A. Mayr, H. Sticki, H.K. Muller, K. Denner, H. Singer The smallpox vaccination strain MVA: Marker, genetic structure, experience...
Primed tumor-reactive multifunctional CD62L+ human CD8+ T cells for immunotherapy T cell-mediated immunotherapy against malignancies has been shown to be effective for certain types of cancer. However, ex vivo expansion of tumor-reactive... Matthias,Wölfl,Katharina,... - 《Cancer Immunology Imm...
CD8+ tissue-resident memory T (TRM) cells in the epidermis are part of a highly sensitive sentinel system that can rapidly respond to previously encountered pathogens. Their formation requires transforming growth factor-β (TGFβ), an abundant cytokine with broad functions in the immune system. ...
To look for surrogate markers in HIV-1 infection that can predict the decline of CD4+ T cells. Multiparameter flow cytometric analyses of CD8+ lymphocytes were performed. These cells were investigated for their expression of the activation marker CD38+ within the naive (CD45RA+) and primed (...
Inhibition does not involve Ab to the virus capsid, as it is observed in animals lacking B cells. CD8-restricted virus-specific T cell responses are not required, as priming to virus without CTL induction is associated with inhibition. However, IL-10(-/-) mice, in contrast to IL-10(+/...