CD8(+) T?cellsIL-21LCMVPDL1T cell exhaustioncancerchronic infectiondendritic cellsimmunotherapyCD8+ Tcell exhaustion impedes control of chronic viral infection; yet how new Tcell responses are mounted during chronic infection is unclear. Unlike Tcells primed at the onset of infection that rapidly ...
Fig. 2: αCD4 leads to new wave of CD8+ T cell priming, and Tx supports cytotoxicity of these cells in the tumor. a, b Flow cytometry quantification (mean ± SD) of CD4+ T cells (gated on single cell/live/CD45+/CD3+NK1.1−/CD4+) and Tregs (gated on single cell/live/...
Priming CD8+T cells with dendritic cells matured using TLR4and TLR7/8ligands together enh-ances generation of CD8+T cells retaining CD28. Pufnock JS,Cigal M,Rolczynski LS,et al. Blood . 2011Pufnock JS, Cigal M, Rolczynski LS, et al. Priming CD8+ T cells with dendritic cells ...
Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon. Eur J Immunol 2004; 34: 194-199.Chen, W., Masterman, K. A., Basta, S., Mansour Haeryfar, S. M., Dimopoulos, N., Knowles, B., Bennink, J. R., and Yewdell, J. W. (2004). Cross-...
T cells In Vivo Does Not Require LMP7-Containing Immunoproteasomes doi:10.1038/jid.2011.454LETTERS to the editorLEISHMANIACD8 antigenA letter to the editor is presented which discusses the priming of Leishmania-reactive CD8 T cells in vivo, which does not require LMP7 to conta...
The cellular dynamics underlying activation of CD8+ T cells by dendritic cells (DCs) in the lymph node are not known. Here we have tracked the behavior of T cells and DCs by subjecting intact lymph nodes to real-time two-photon microscopy. We show that DCs scan at least 500 different T...
However, cytokines that are produced by cells of the innate immune system also have a key role in CD8 + T-cell responses, by enhancing 'cross-presentation' and/or inducing CD8 + T-cell priming and differentiation. Here, we discuss how innate cytokine responses regulate CD8 + T-cell ...
CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC? RNA transfection is a standard method to load dendritic cells (DC) with antigen for therapeutic cancer vaccination. While electroporation yields high trans... N Schaft,V Wellner,Christian Wohn… - 《Cancer...
ARTICLES Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes Heather D Hickman1, Kazuyo Takeda1, Cara N Skon1, Faith R Murray1, Scott E Hensley1, Joshua Loomis2, Glen N Barber2, Jack R Bennink1 & Jonathan W Yewdell1 It is uncertain how ...
Dendritic cells (DC) generated after a short-term exposure of monocytes to IFN-伪 and GM-CSF (IFN-DC) are highly effective in inducing cross-priming of CD8T cells against viral antigens. We have investigated the mechanisms responsible for the special attitude of these DC and ...