Dikopoulos N, Wegenka U, Kroger A, Hauser H, Schirmbeck R, Reimann J (2004) Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with naive CD8+ T cells in the mouse. Hepatology 39(5):1256–1266Dikopoulos, N., Wegenka, U., Kroger, A., Hauser, H., ...
CD8 T cells primed by transplantation recognize allogeneic class I MHC molecules expressed on graft vascular endothelium and contribute to allograft injury. We previously showed that immune cell-derived complement activation fragments are integral to T cell activation/expansion. Herein we tested the impact...
While it is well known that CD4+ T cells and B cells collaborate for antibody production, our group previously reported that CD8+ T cells down-regulate alloantibody responses following transplantation. However, the exact mechanism involved in CD8+ T cell–mediated down-regulation of alloantibody re...
Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with nave CD8+ T cells in the mouse Large number of T cells traffic through the liver. In order to examine the effects of such traffic on the phenotype of hepatocytes, we vaccinated mice using DNA vaccines ...
To prevent bystander destruction of healthy host tissues, cytotoxic CD8(+) T lymphocytes are fitted with specific receptors that direct their destructive forces specifically against chosen targets. We show here, however, that anti-H-Y monospecific, H-2(b-restricted MataHari CD8(+) T cells reject...
Primed tumor-reactive multifunctional CD62L+ human CD8+ T cells for immunotherapy T cell-mediated immunotherapy against malignancies has been shown to be effective for certain types of cancer. However, ex vivo expansion of tumor-reactive... Matthias,Wölfl,Katharina,... - 《Cancer Immunology Imm...
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection J. Virol., 68 (1994), pp. 8056-8063 Google Scholar 14 A. Mayr, H. Sticki, H.K. Muller, K. Denner, H. Singer The smallpox vaccination strain MVA: Marker, genetic structure, experience...
CD8+ tissue-resident memory T (TRM) cells in the epidermis are part of a highly sensitive sentinel system that can rapidly respond to previously encountered pathogens. Their formation requires transforming growth factor-β (TGFβ), an abundant cytokine with broad functions in the immune system. ...
To look for surrogate markers in HIV-1 infection that can predict the decline of CD4+ T cells. Multiparameter flow cytometric analyses of CD8+ lymphocytes were performed. These cells were investigated for their expression of the activation marker CD38+ within the naive (CD45RA+) and primed (...
Inhibition does not involve Ab to the virus capsid, as it is observed in animals lacking B cells. CD8-restricted virus-specific T cell responses are not required, as priming to virus without CTL induction is associated with inhibition. However, IL-10(-/-) mice, in contrast to IL-10(+/...