Dikopoulos N, Wegenka U, Kroger A, Hauser H, Schirmbeck R, Reimann J (2004) Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with naive CD8+ T cells in the mouse. Hepatology 39(5):1256–1266Dikopoulos, N., Wegenka, U., Kroger, A., Hauser, H., ...
CD8 T cells primed by transplantation recognize allogeneic class I MHC molecules expressed on graft vascular endothelium and contribute to allograft injury. We previously showed that immune cell-derived complement activation fragments are integral to T cell activation/expansion. Herein we tested the impact...
Additionally, this review focuses on type 17 immunity interconnecting multiple organs in autoimmune conditions, with a particular emphasis on the pathogenesis of autoimmune arthritis and neuroinflammation driven by T cells primed within the gut microenvironment....
Furthermore, CD8+ T cells require FasL, perforin and allospecificity to down-regulate posttransplant alloantibody production. In vivo CD8-mediated clearance of alloprimed B cells was also FasL- and perforin-dependent. In vitro data demonstrated that recipient CD8+ T cells directly induce apoptosis...
CD8 T CELLS PRODUCING IFN-G AND IL-17 INDUCE THE INNATE IMMUNE RESPONSE REQUIRED FOR T CELL MEDIATED RESPONSES IN THE SKIN (96.3) Contact hypersensitivity (CHS) is a CD8 T cell-mediated response to skin sensitization and challenge with hapten. Hapten-primed CD8 T cell recruitment into... D...
Our data indicate that Langerhans cells from MHC class II-deficient mice undergo functional activation upon short-term culture, stimulate hapten-specific CD8+ T cells in vitro, and can prime T cells in vivo. Materials and Methods Animals MHC class II-deficient mice that have a disruption of ...
We found that when equivalent numbers of virus-specific cells were transferred into virus-susceptible mice, protection from disease was similar whether donor, immune mice were primed as neonates or adults, and IL-4 did not alter in vivo virus-specific CD8+ memory cell effector function. Hence, ...
First, NETs exerted an inhibitory role in the amount and function of CD8+ T cells. The infiltrating rate of CD8+ T lymphocytes was inversely associated with the NETs density in human solid tumors including non-small cell lung cancer (NSCLC) and bladder cancer (BC) [79]. Teijeira Á et...
We annotate these cells as dendritic cells (DC), monocytes (Mono), natural killer cells (NK), B-cells (B), CD4+ T-cells (CD4 T), and CD8+ T-cells (CD8 T). To account for this heterogeneity, we build a context aware joint representation learning (JRL) SupirFactor model (see the ...
Introduction Interleukin-15 (IL-15) activates and expands both CD8T cells and NK cells but not immunosuppressive Tregcells. While IL-15 is an attractive asset for cancer immunotherapy, its systemic administration is limited by toxicities. To limit IL-15 systemic exposure, we have developed DeepTM...