Liver-primed CD8+ T cells suppress antiviral adaptive im- munity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice. Hepatology 2014; 59: 1351-65.Dolina JS, Braciale TJ, Hahn YS. Liver-primed CD8+ T cells suppress antiviral ...
CD8 T cells primed by transplantation recognize allogeneic class I MHC molecules expressed on graft vascular endothelium and contribute to allograft injury. We previously showed that immune cell-derived complement activation fragments are integral to T cell activation/expansion. Herein we tested the impact...
While it is well known that CD4+ T cells and B cells collaborate for antibody production, our group previously reported that CD8+ T cells down-regulate alloantibody responses following transplantation. However, the exact mechanism involved in CD8+ T cell–mediated down-regulation of alloantibody re...
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection J. Virol., 68 (1994), pp. 8056-8063 Google Scholar 14 A. Mayr, H. Sticki, H.K. Muller, K. Denner, H. Singer The smallpox vaccination strain MVA: Marker, genetic structure, experience...
Additionally, this review focuses on type 17 immunity interconnecting multiple organs in autoimmune conditions, with a particular emphasis on the pathogenesis of autoimmune arthritis and neuroinflammation driven by T cells primed within the gut microenvironment....
Previous priming of donor-specific T cells through rejection of B10.A, but not third party, skin grafts prevented the effects of DST/αCD40L on prolonging survival of B10.A hearts. Moreover, adoptive transfer of CD3+, CD4+ or CD8+ T cells from B10.A skin-graft-primed animals prevented ...
Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with nave CD8+ T cells in the mouse Large number of T cells traffic through the liver. In order to examine the effects of such traffic on the phenotype of hepatocytes, we vaccinated mice using DNA vaccines ...
We have shown that CD8(+) CTLs are the key mediators of accelerated rejection, and that CD8(+) T cells represent the prime targets of CD154 blockade in sensitized mouse recipients of cardiac allografts. However, the current protocols require CD154 blockade at the time of sensitization, whereas...
Our results define a liver-primed memory T cell population that is generated by nonprofessional APCs, which rescues T cells from tolerization by immature DCs and enables the subsequent induction of pathogen-specific CTL immunity. Results Naive CD8+ T Cells Primed by Cross-Presenting LSECs in the...
First, NETs exerted an inhibitory role in the amount and function of CD8+ T cells. The infiltrating rate of CD8+ T lymphocytes was inversely associated with the NETs density in human solid tumors including non-small cell lung cancer (NSCLC) and bladder cancer (BC) [79]. Teijeira Á et...